Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds

被引：22

作者：

Acemoglu, M ^{[1
]}

Allmendinger, T

Calienni, J

Cercus, J

Loiseleur, O

Sedelmeier, GH

Xu, D

机构：

[1] Novartis Pharma AG, Chem & Analyt Dev, CH-4002 Basel, Switzerland

[2] Novartis Inst Biomed Res, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 50期

关键词：

diarylamines; N-aryl oxyindoles; 2-(N-arylamino)-phenyl-acetic acids; NSAID's;

D O I：

10.1016/j.tet.2004.09.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures. in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：11571 / 11586

页数：16

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