HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia

被引：18

作者：

Wu, Jing-Shan

James, Ian ^{[3
,4
]}

Qiu, Wei ^{[6
]}

Castley, Alison ^{[2
]}

Christiansen, Frank T. ^{[2
,5
]}

Carroll, William M.

Mastaglia, Frank L.

Kermode, Allan G. ^{[1
]}

机构：

[1] Univ Western Australia, Queen Elizabeth II Med Ctr, Australian Neuromuscular Res Inst,Dept Neurol, Sir Charles Gairdner Hosp,Ctr Neuromuscular & Neu, Perth, WA 6009, Australia

[2] PathWest Royal Perth Hosp, Dept Clin Immunol & Immunogenet, Perth, WA, Australia

[3] Murdoch Univ, Ctr Clin Immunol & Biomed Stat, Perth, WA, Australia

[4] Royal Perth Hosp, Perth, WA, Australia

[5] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA 6009, Australia

[6] Sun Yet Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 219卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Multiple sclerosis; Human Leukocyte Antigen (HLA); Susceptibility; Multiple Sclerosis Severity Score; MAJOR HISTOCOMPATIBILITY COMPLEX; DISEASE SEVERITY; CLASS-II; DIAGNOSTIC-CRITERIA; HLA-DR; SUSCEPTIBILITY; ASSOCIATION; IMMUNOGENETICS; GUIDELINES; HAPLOTYPE;

D O I：

10.1016/j.jneuroim.2009.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Susceptibility to multiple sclerosis (MS) has been consistently associated with the Human Leukocyte Antigen (HLA)-DRB1*1501 genotype, however effects on disease severity and clinical outcome have varied in different populations We present the results of a high-resolution HLA-DRB1 genotyping and genotype-phenotype correlation study in a large West Australian MS cohort Our findings indicate that in this population, which is of largely Anglo-Celtic and Northern European origin, HLA-DRB1*1501 is not only a strong determinant of disease risk but may also be associated with disease severity as measured by the Multiple Sclerosis Severity Score (MSSS), with the MSSS increasing by an estimated 0.51 per DRB1*1501 allele We also found evidence that the HLA-DRB1*1201 allele is associated with less severe disease. (C) 2009 Elsevier B V All rights reserved

引用

页码：109 / 113

页数：5

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