Ototoxicity associated with topical administration of diclofenac sodium as an otic drop: An experimental animal study

被引:5
作者
Acioglu, Engin [1 ,4 ]
Yigit, Ozgur [1 ]
Onur, Firat [1 ,3 ]
Atas, Ahmet [2 ]
Server, Ela Araz [1 ]
Kara, Eyup [2 ]
机构
[1] Univ Hlth Sci, Istanbul Training & Res Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Istanbul, Turkey
[2] Istanbul Univ Fac Hlth Sci, Dept Audiol, Istanbul, Turkey
[3] Babaeski State Hosp, Dept Otolaryngol Head & Neck Surg, Babaeski, Kirklareli, Turkey
[4] Mem Atalehir Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey
关键词
ototoxicity; Diclofenac sodium; Anti-inflammatory; ABR; SALICYLATE; CHILDREN; EAR;
D O I
10.1016/j.ijporl.2017.04.039
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objectives: The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. Methods: Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated. Results: No significant difference were observed between the pre and post -treatment click response, 1 kHz and 8 kHz response threshold levels after isotonic sodium chloride administration. All threshold levels were elevated in the positive control group. In the low and high dose diclofenac sodium groups, click response, 1 kHz and 8 kHz response threshold levels were significantly higher compared to the baseline values. Pre and post-treatmentmean threshold level changes were not significantly different between the low and high dose diclofenac sodium groups. Pre and post-treatmentmean threshold level changes in the gentamicin group were not significantly different from low or high dose diclofenac sodium groups. Conclusion: Diclofenac sodium, considered as an analgesic and anti-inflammatory otic preparation, is shown to be as ototoxic as gentamicin in chronic use which may lead to loss of hearing especially when used topically in chronic otitis cases with tympanic membrane damage.(C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:110 / 115
页数:6
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