Radical causes of cancer

被引：1304

作者：

Hussain, SP ^{[1
]}

Hofseth, LJ ^{[1
]}

Harris, CC ^{[1
]}

机构：

[1] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrc1046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Free radicals are ubiquitous in our body and are generated by normal physiological processes, including aerobic metabolism and inflammatory responses, to eliminate invading pathogenic microorganisms. Because free radicals can also inflict cellular damage, several defences have evolved both to protect our cells from radicals - such as antioxidant scavengers and enzymes - and to repair DNA damage. Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved. In particular, we highlight the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.

引用

页码：276 / 285

页数：10

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