Total Synthesis of Acetylcholinesterase Inhibitor Macakurzin C

被引：7

作者：

Lee, Dongjoo ^{[1
]}

Shin, Iljin ^{[1
]}

Ko, Eunjae ^{[1
]}

Lee, Kiyoun ^{[2
,3
]}

Seo, Seung-Yong ^{[4
]}

Kim, Hyoungsu ^{[1
]}

机构：

[1] Ajou Univ, Coll Pharm, Suwon 443749, South Korea

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Gachon Univ, Coll Pharm, Inchon 406840, South Korea

来源：

SYNLETT | 2014年 / 25卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

total synthesis; natural products; aromatic Claisen rearrangement; acetylcholinesterase inhibitors; flavonoids; STEREOCONTROLLED SYNTHESIS; REARRANGEMENT; FLAVONOIDS; CLAISEN;

D O I：

10.1055/s-0034-1378904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise total synthesis of macakurzin C has been accomplished in nine steps (21% overall yield) from commercially available phloroglucinol, featuring a sequential aromatic Claisen rearrangement-cyclization.

引用

收藏

页码：2794 / 2796

页数：3

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