Elemental sulfur-promoted one-pot synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles and their derivatives

被引：21

作者：

Li, Zhengyu ^{[1
,2
]}

Dong, Jingnan ^{[1
,2
]}

Wang, Junwen ^{[1
,2
]}

Yang, Ding-Yah ^{[3
]}

Weng, Zhiqiang ^{[1
,2
]}

机构：

[1] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China

[2] Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China

[3] Tunghai Univ, Dept Chem, 1727,Sec 4,Taiwan Blvd, Taichung 40704, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 87期

基金：

中国国家自然科学基金;

关键词：

C-H TRIFLUOROETHYLATION; CATALYZED DECARBOXYLATIVE TRIFLUOROETHYLATION; ARYLBORONIC ACIDS; ARYL IODIDES; 2,2,2-TRIFLUOROETHYLATION; BENZOXAZOLES; ALKYLATIONS; ALKYNES; MILD;

D O I：

10.1039/c9cc06822h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and direct strategy has been developed for the synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles by reaction of o-aminophenols and 2-bromo-3,3,3-trifluoropropene in the presence of elemental sulfur under metal-free conditions. The scope of this methodology was further extended to the synthesis of the trifluoroethylated benzothiazole and benzoimidazole derivatives. A plausible mechanism was proposed on the basis of isolation and characterization of a thioamide intermediate.

引用

页码：13132 / 13135

页数：4

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