Manganese(I)-Catalyzed C-H 3,3-Difluoroallylation of Pyridones and Indoles

被引：83

作者：

Ni, Jiabin ^{[1
,2
,3
]}

Zhao, Hongchuan ^{[1
,2
,3
]}

Zhang, Ao ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 12期

关键词：

BOND FORMATION; COBALT CATALYSIS; MANGANESE; ACTIVATION; FUNCTIONALIZATION; ALKYNES; ESTERS; ACID; ALKENYLATION; ALKYNYLATION;

D O I：

10.1021/acs.orglett.7b01282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient C-H activation approach for the direct 3,3-difhioroallylation of 2-pyridones and indoles is herein reported using a manganese(I) complex as the catalyst. A broad range of substrates with diverse functional groups were tolerated. Moreover late-stage C-H functionalization of bioactive molecules was achieved in good yield.

引用

页码：3159 / 3162

页数：4

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