Focal seizures with impaired awareness as long-term neurological complication of COVID-19: a case report

被引：12

作者：

Bozzali, Marco ^{[1
,2
]}

Grassini, Alberto ^{[1
]}

Morana, Giovanni ^{[1
]}

Zotta, Michela ^{[3
]}

Cabras, Sara ^{[1
]}

Romagnolo, Alberto ^{[1
]}

Artusi, Carlo Alberto ^{[1
]}

Montalenti, Elisa ^{[4
]}

Rizzone, Mario Giorgio ^{[1
]}

Garbossa, Diego ^{[1
]}

Montanaro, Elisa ^{[4
]}

Cercignani, Mara ^{[2
]}

Lopiano, Leonardo ^{[1
,4
]}

机构：

[1] Univ Torino, Dept Neurosci Rita Levi Montalcini, Via Cherasco 15, I-10126 Turin, Italy

[2] Univ Sussex, Dept Neurosci, Brighton & Sussex Med Sch, Brighton, E Sussex, England

[3] AOU Citta Salute & Sci Torino, Nucl Med Unit, Dept Diagnost Imaging, Turin, Italy

[4] AOU Citta Salute & Sci Torino, Neurol Unit 2, I-10124 Turin, Italy

来源：

NEUROLOGICAL SCIENCES | 2021年 / 42卷 / 07期

关键词：

COVID-19; Epilepsy; Focal seizures with impaired awareness; Encephalitis; INFECTION;

D O I：

10.1007/s10072-021-05233-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report here the first case of a young individual otherwise healthy, who presented with frequent focal seizures with impaired awareness as a possible long-term complication of severe acute respiratory syndrome coronavirus-2 infection. Seizures were documented by electroencephalography and responded clinically and neuro-physiologically to antiseizure therapy. The patient underwent an extensive investigation including cerebrospinal fluid examination, conventional and quantitative brain magnetic resonance imaging, and 18-FDG positron emission tomography. Beyond the clinical interest, this case contributes to clarify the possible pathways by which SARS-CoV-2 may enter the central nervous system and cause long-term neurological complications.

引用

页码：2619 / 2623

页数：5

共 11 条

[1] Seizures associated with coronavirus infections [J].

Asadi-Pooya, Ali A. .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2020, 79 :49-52

[2] Nasal pain as an aura: Amygdala origin? [J].

Heo, Kyoung ;

Kim, Kyung Min ;

Han, Seung Min ;

Cho, Kyoo Ho ;

Chu, Min Kyung .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2020, 83 :13-16

[3] Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice [J].

Jacomy, Helene ;

Fragoso, Gabriela ;

Almazan, Guillermina ;

Mushynski, Walter E. ;

Talbot, Pierre J. .

VIROLOGY, 2006, 349 (02) :335-346

[4] Bilateral transient olfactory bulb edema during COVID-19-related anosmia [J].

Laurendon, Thomas ;

Radulesco, Thomas ;

Mugnier, Justine ;

Gerault, Melanie ;

Chagnaud, Christophe ;

El Ahmadi, Ahmed-Ali ;

Varoquaux, Arthur .

NEUROLOGY, 2020, 95 (05) :224-225

[5]

Mao L, 2020, Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study

[6] Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus [J].

McCray, Paul B., Jr. ;

Pewe, Lecia ;

Wohlford-Lenane, Christine ;

Hickey, Melissa ;

Manzel, Lori ;

Shi, Lei ;

Netland, Jason ;

Jia, Hong Peng ;

Halabi, Carmen ;

Sigmund, Curt D. ;

Meyerholz, David K. ;

Kirby, Patricia ;

Look, Dwight C. ;

Perlman, Stanley .

JOURNAL OF VIROLOGY, 2007, 81 (02) :813-821

[7] Neurological Damage by Coronaviruses: A Catastrophe in the Queue! [J].

Mishra, Ritu ;

Banerjea, Akhil C. .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[8] A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 [J].

Moriguchi, Takeshi ;

Harii, Norikazu ;

Goto, Junko ;

Harada, Daiki ;

Sugawara, Hisanori ;

Takamino, Junichi ;

Ueno, Masateru ;

Sakata, Hiroki ;

Kondo, Kengo ;

Myose, Natsuhiko ;

Nakao, Atsuhito ;

Takeda, Masayuki ;

Haro, Hirotaka ;

Inoue, Osamu ;

Suzuki-Inoue, Katsue ;

Kubokawa, Kayo ;

Ogihara, Shinji ;

Sasaki, Tomoyuki ;

Kinouchi, Hiroyuki ;

Kojin, Hiroyuki ;

Ito, Masami ;

Onishi, Hiroshi ;

Shimizu, Tatsuya ;

Sasaki, Yu ;

Enomoto, Nobuyuki ;

Ishihara, Hiroshi ;

Furuya, Shiomi ;

Yamamoto, Tomoko ;

Shimada, Shinji .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 94 :55-58

[9] Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms [J].

Neumann, Bernhard ;

Schmidbauer, Moritz L. ;

Dimitriadis, Konstatinos ;

Otto, Soeren ;

Knier, Benjamin ;

Niesen, Wolf-Dirk ;

Hosp, Jonas A. ;

Guenther, Albrecht ;

Lindemann, Sarah ;

Nagy, Gabor ;

Steinberg, Tim ;

Linker, Ralf A. ;

Hemmer, Bernhard ;

Boesel, Julian .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 418

[10] SPREAD OF A NEUROTROPIC MURINE CORONAVIRUS INTO THE CNS VIA THE TRIGEMINAL AND OLFACTORY NERVES [J].

PERLMAN, S ;

JACOBSEN, G ;

AFIFI, A .

VIROLOGY, 1989, 170 (02) :556-560

← 1 2 →