The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

被引:121
|
作者
Savant, Sudha S. [1 ]
Sriramkumar, Shruthi [2 ]
O'Hagan, Heather M. [1 ,3 ]
机构
[1] Indiana Univ Sch Med, Med Sci, Bloomington, IN 47405 USA
[2] Indiana Univ, Cell Mol & Canc Biol Grad Program, Bloomington, IN 47405 USA
[3] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA
关键词
inflammation; epithelial ovarian cancer; cytokines; reactive oxygen species; growth factors; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANCHORAGE-INDEPENDENT GROWTH; FACTOR RECEPTOR EXPRESSION; INTERLEUKIN-6; SERUM-LEVELS; C-REACTIVE PROTEIN; NF-KAPPA-B; LYSOPHOSPHATIDIC ACID; CELL-PROLIFERATION;
D O I
10.3390/cancers10080251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC.
引用
收藏
页数:30
相关论文
共 50 条
  • [41] Current insights into the metastasis of epithelial ovarian cancer-hopes and hurdles
    Yousefi, Meysam
    Dehghani, Sadegh
    Nosrati, Rahim
    Ghanei, Mahmoud
    Salmaninejad, Arash
    Rajaie, Sara
    Hasanzadeh, Malihe
    Pasdar, Alireza
    CELLULAR ONCOLOGY, 2020, 43 (04) : 515 - 538
  • [42] The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone
    Goebel, Andy
    Dell'Endice, Stefania
    Jaschke, Nikolai
    Paehlig, Sophie
    Shahid, Amna
    Hofbauer, Lorenz C.
    Rachner, Tilman D.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (10)
  • [43] Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer
    Horio, Maiko
    Kato, Takuya
    Mii, Shinji
    Enomoto, Atsushi
    Asai, Masato
    Asai, Naoya
    Murakumo, Yoshiki
    Shibata, Kiyosumi
    Kikkawa, Fumitaka
    Takahashi, Masahide
    CANCER MEDICINE, 2012, 1 (02): : 218 - 229
  • [44] The implication of IL-6 in the invasiveness and chemoresistance of ovarian cancer cells. Systematic review of its potential role as a biomarker in ovarian cancer patients
    Szulc-Kielbik, Izabela
    Kielbik, Michal
    Nowak, Marek
    Klink, Magdalena
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021, 1876 (02):
  • [45] Breast Cancer Metastasis: Are Cytokines Important Players During Its Development and Progression?
    Angelica Mendez-Garcia, Lucia
    Elizabeth Nava-Castro, Karen
    de Lourdes Ochoa-Mercado, Tania
    Isabel Palacios-Arreola, Margarita
    Alejandra Ruiz-Manzano, Rocio
    Segovia-Mendoza, Mariana
    Solleiro-Villavicencio, Helena
    Cazarez-Martinez, Cinthia
    Morales-Montor, Jorge
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2019, 39 (01): : 39 - 55
  • [46] Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer
    Klaschik, Sven
    Gehlen, Jennifer
    Neumann, Claudia
    Keyver-Paik, Mignon-Denise
    Soehle, Martin
    Frede, Stilla
    Velten, Markus
    Hoeft, Andreas
    Hilbert, Tobias
    MEDIATORS OF INFLAMMATION, 2019, 2019
  • [47] Expression and clinical role of TCTP in epithelial ovarian cancer
    Chen, Chen
    Deng, Yan
    Hua, Minhui
    Xi, Qinghua
    Liu, Rong
    Yang, Shuyun
    Liu, Jian
    Zhong, Jianxin
    Tang, Meilan
    Lu, Shumin
    Zhang, Zhimei
    Min, Xiao
    Tang, Chunhui
    Wang, Yingying
    JOURNAL OF MOLECULAR HISTOLOGY, 2015, 46 (02) : 145 - 156
  • [48] The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis
    Guan, Xiaohan
    Fu, Yanwen
    Liu, Yixin
    Cui, Mingxuan
    Zhang, Caishun
    Zhang, Qing
    Li, Chunmei
    Zhao, Jian
    Wang, Chaofan
    Song, Jiarun
    Dong, Jing
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [49] Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer
    Wu, Buchu
    Hu, Ke
    Li, Shu
    Zhu, Jing
    Gu, Liying
    Shen, Haoran
    Hambly, Brett D.
    Bao, Shisan
    Di, Wen
    ONCOLOGY REPORTS, 2012, 27 (01) : 101 - 108
  • [50] Risk Factors for Appendiceal Metastasis with Epithelial Ovarian Cancer
    Kokanali, Mahmut Kuntay
    Guzel, Ali Irfan
    Erkilinc, Selcuk
    Tokmak, Aytekin
    Topcu, Hasan Onur
    Gungor, Tayfun
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (06) : 2689 - 2692