The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

被引:121
|
作者
Savant, Sudha S. [1 ]
Sriramkumar, Shruthi [2 ]
O'Hagan, Heather M. [1 ,3 ]
机构
[1] Indiana Univ Sch Med, Med Sci, Bloomington, IN 47405 USA
[2] Indiana Univ, Cell Mol & Canc Biol Grad Program, Bloomington, IN 47405 USA
[3] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA
关键词
inflammation; epithelial ovarian cancer; cytokines; reactive oxygen species; growth factors; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANCHORAGE-INDEPENDENT GROWTH; FACTOR RECEPTOR EXPRESSION; INTERLEUKIN-6; SERUM-LEVELS; C-REACTIVE PROTEIN; NF-KAPPA-B; LYSOPHOSPHATIDIC ACID; CELL-PROLIFERATION;
D O I
10.3390/cancers10080251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC.
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页数:30
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