The Causative Organisms of Bacterial Meningitis in Korean Children in 1996-2005

被引：39

作者：

Cho, Hye Kyung ^{[1
]}

Lee, Hyunju ^{[1
]}

Kang, Jin Han ^{[2
]}

Kim, Kwang Nam ^{[3
]}

Kim, Dong Soo ^{[4
]}

Kim, Yun Kyung ^{[5
]}

Kim, Jung Soo ^{[6
]}

Kim, Jong-Hyun ^{[2
]}

Kim, Chang Hwi ^{[7
]}

Kim, Hwang Min ^{[8
]}

Park, Su-Eun ^{[9
]}

Oh, Sung Hee ^{[10
]}

Chung, Eun Hee ^{[11
]}

Cha, Sung Ho ^{[12
]}

Choi, Young Youn ^{[13
]}

Hur, Jae Kyun ^{[2
]}

Hong, Young Jin ^{[14
]}

Lee, Hoan Jong ^{[15
]}

Kim, Kyung-Hyo ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Pediat, Sch Med, Seoul 158710, South Korea

[2] Catholic Univ Korea, Coll Med, Seoul, South Korea

[3] Hallym Univ, Coll Med, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Seoul, South Korea

[5] Korea Univ, Coll Med, Ansan, South Korea

[6] Chonbuk Natl Univ, Coll Med, Jeonju, South Korea

[7] Soonchunhyang Univ, Coll Med, Puchon, South Korea

[8] Yonsei Univ, Wonju Coll Med, Wonju, South Korea

[9] Busan Natl Univ, Sch Med, Pusan, South Korea

[10] Hanyang Univ, Coll Med, Seoul 133791, South Korea

[11] Dankook Univ, Coll Med, Cheonan, South Korea

[12] Kyung Hee Univ, Sch Med, Seoul, South Korea

[13] Chonnam Natl Univ, Sch Med, Kwangju, South Korea

[14] Inha Univ, Coll Med, Inchon, South Korea

[15] Seoul Natl Univ, Coll Med, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2010年 / 25卷 / 06期

关键词：

Meningitis; Bacterial; Etiology; Epidemiology; Streptococcus pneumoniae; Haemophilus influenzae; Streptococcus agalactiae; Neisseria meningitidis; PNEUMOCOCCAL CONJUGATE VACCINE; UNITED-STATES; EPIDEMIOLOGY; CHILDHOOD; IMMUNIZATION; ELIMINATION; INFECTIONS; DISEASE;

D O I：

10.3346/jkms.2010.25.6.895

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.

引用

页码：895 / 899

页数：5

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