Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta

被引：28

作者：

Gilden, Don ^{[1
,2
]}

White, Teresa ^{[1
]}

Boyer, Philip J. ^{[4
]}

Galetta, Kristin M. ^{[5
,6
]}

Hedley-Whyte, E. Tessa ^{[7
]}

Frank, Meredith ^{[3
]}

Holmes, Dawn ^{[3
]}

Nagel, Maria A. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Dept Neurol, B-182,12700 E 19th Ave,Rm 5014, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Dept Immunol & Microbiol, Aurora, CO 80045 USA

[3] Dept Environm Hlth, Off Med Examiner, Denver, CO USA

[4] E Carolina Univ, Dept Pathol, Greenville, NC USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 12期

基金：

美国国家卫生研究院;

关键词：

VZV; granulomatous arteritis; granulomatous aortitis; GIANT-CELL ARTERITIS; TEMPORAL ARTERIES; DNA; CLASSIFICATION; REACTIVATION; INVOLVEMENT; CRITERIA; VZV;

D O I：

10.1093/infdis/jiw101

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granulomatous arteritis characterizes the pathology of giant cell arteritis, granulomatous aortitis, and intracerebral varicella zoster virus (VZV) vasculopathy. Because intracerebral VZV vasculopathy and giant cell arteritis are strongly associated with productive VZV infection in cerebral and temporal arteries, respectively, we evaluated human aortas for VZV antigen and VZV DNA. Using 3 different anti-VZV antibodies, we identified VZV antigen in 11 of 11 aortas with pathologically verified granulomatous arteritis, in 1 of 1 cases of nongranulomatous arteritis, and in 5 of 18 control aortas (28%) obtained at autopsy. The presence of VZV antigen in granulomatous aortitis was highly significant (P = .0001) as compared to control aortas, in which VZV antigen was never associated with pathology, indicating subclinical reactivation. VZV DNA was found in most aortas containing VZV antigen. The frequent clinical, radiological, and pathological aortic involvement in patients with giant cell arteritis correlates with the significant detection of VZV in granulomatous aortitis.

引用

页码：1866 / 1871

页数：6

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