Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA helicase

被引：227

作者：

Wu-Scharf, D ^{[1
]}

Jeong, BR ^{[1
]}

Zhang, CM ^{[1
]}

Cerutti, H ^{[1
]}

机构：

[1] Univ Nebraska, Sch Biol Sci & Plant Sci Initiat, Beadle Ctr E211, Lincoln, NE 68588 USA

来源：

SCIENCE | 2000年 / 290卷 / 5494期

关键词：

D O I：

10.1126/science.290.5494.1159

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The molecular mechanism(s) responsible for posttranscriptional gene silencing and RNA interference remain poorly understood. We have cloned a gene (Mut6) from the unicellular green alga Chlamydomonas reinhardtii that is required for the silencing of a transgene and two transposon families, Mut6 encodes a protein that is highly homologous to RNA helicases of the DEAH-box family, This protein is necessary for the degradation of certain aberrant RNAs, such as improperly processed transcripts, which are often produced by transposons and some transgenes.

引用

页码：1159 / 1162

页数：4

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