Italian association of clinical endocrinologists (AME) position statement: drug therapy of osteoporosis

被引：37

作者：

Vescini, F. ^{[1
]}

Attanasio, R. ^{[2
]}

Balestrieri, A. ^{[3
]}

Bandeira, F. ^{[4
]}

Bonadonna, S. ^{[5
]}

Camozzi, V. ^{[6
]}

Cassibba, S. ^{[7
]}

Cesareo, R. ^{[8
]}

Chiodini, I. ^{[9
]}

Francucci, C. Maria ^{[10
,11
]}

Gianotti, L. ^{[12
]}

Grimaldi, F. ^{[1
]}

Guglielmi, R. ^{[13
]}

Madeo, B. ^{[14
]}

Marcocci, C. ^{[15
]}

Palermo, A. ^{[16
]}

Scillitani, A. ^{[17
]}

Vignali, E. ^{[18
]}

Rochira, V. ^{[19
]}

Zini, M. ^{[20
]}

机构：

[1] Azienda Osped Univ Santa Maria Misericordia, Endocrinol & Metab Dis Unit, Ple SM Misericordia 15, I-33100 Udine, Italy

[2] Galeazzi Inst IRCCS, Serv Endocrinol, Milan, Italy

[3] Osped Gen Provinciale M Bufalini, Dept Internal Med, Unit Endocrinol & Diabetol, Cesena, Italy

[4] Univ Pernambuco, Div Endocrinol Diabet & Bone Dis, Agamenon Magalhaes Hosp, Sch Med, Recife, PE, Brazil

[5] Ist Auxol Italiano, Milan, Italy

[6] Univ Padua, Dept Med, Unit Endocrinol, Padua, Italy

[7] Papa Giovanni XXIII Hosp, Endocrinol & Diabetol, Bergamo, Italy

[8] S Maria Goretti Hosp, Endocrinol, Latina, Italy

[9] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[10] INRCA Ancona, Post Acute & Long Term Care Dept, Ancona, Italy

[11] San Pier Damiano Hosp, Villa Maria Grp Care & Res, Faenza, Ravenna, Italy

[12] S Croce Carle Hosp, Endocrinol & Metab Dis, Cuneo, Italy

[13] Regina Apostolorum Hosp, Endocrinol Unit, Rome, Italy

[14] Univ Modena & Reggio Emilia, Integrated Dept Med Endocrinol & Metab, Geriatr, Modena, Italy

[15] Univ Hosp Pisa, Dept Clin & Expt Med, Endocrine Unit 2, Pisa, Italy

[16] Univ Campus Biomed, Dept Endocrinol & Diabet, Rome, Italy

[17] Casa Sollievo Sofferenza IRCCS, Endocrinol, San Giovanni Rotondo, Italy

[18] Univ Hosp Pisa, Dept Clin & Expt Med, Pisa, Italy

[19] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Unit Endocrinol, Modena, Italy

[20] Arcispedale S Maria Nuova IRCCS, Endocrinol Unit, Reggio Emilia, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2016年 / 39卷 / 07期

关键词：

Osteoporosis; Fracture; Treatment; Bisphosphonates; Teriparatide; Strontium ranelate; Denosumab; SERMs; Adherence; Side effects; Non-responder; Male osteoporosis; Drug-induced osteoporosis; Androgen deprivation; Aromatase inhibitors; Length of therapy; BONE-MINERAL DENSITY; ANDROGEN-DEPRIVATION THERAPY; VERTEBRAL FRACTURE RISK; ESTROGEN PLUS PROGESTIN; NONMETASTATIC PROSTATE-CANCER; HEALTHY POSTMENOPAUSAL WOMEN; RANDOMIZED CONTROLLED-TRIAL; VITAMIN-D SUPPLEMENTATION; PARATHYROID-HORMONE; 1-34; YEARLY ZOLEDRONIC ACID;

D O I：

10.1007/s40618-016-0434-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of osteoporosis is aimed to prevent fragility fractures and to stabilize or increase bone mineral density. Several drugs with different efficacy and safety profiles are available. The long-term therapeutic strategy should be planned, and the initial treatment should be selected according to the individual site-specific fracture risk and the need to give the maximal protection when the fracture risk is highest (i.e. in the late life). The present consensus focused on the strategies for the treatment of postmenopausal osteoporosis taking into consideration all the drugs available for this purpose. A short revision of the literature about treatment of secondary osteoporosis due both to androgen deprivation therapy for prostate cancer and to aromatase inhibitors for breast cancer was also performed. Also premenopausal females and males with osteoporosis are frequently seen in endocrine settings. Finally particular attention was paid to the tailoring of treatment as well as to its duration.

引用

页码：807 / 834

页数：28

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