Abnormal self-schema in semantic memory in major depressive disorder: Evidence from event-related brain potentials

被引:24
作者
Kiang, Michael [1 ,2 ]
Farzan, Faranak [1 ,2 ]
Blumberger, Daniel M. [1 ,2 ]
Kutas, Marta [3 ,4 ]
McKinnon, Margaret C. [5 ,6 ]
Kansal, Vinay [6 ]
Rajji, Tarek K. [1 ,2 ]
Daskalakis, Zafiris J. [1 ,2 ]
机构
[1] Ctr Addict & Mental Hlth, Room 705,250 Coll St, Toronto, ON M5T 1R8, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[3] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[5] St Josephs Healthcare Hamilton, Hamilton, ON, Canada
[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
基金
加拿大健康研究院;
关键词
Major depressive disorder; Semantic memory; Self-schema; Electroencephalography; Event-related potentials; Language; COGNITIVE THERAPY; POSITIVITY BIAS; DSM-IV; N400; BIOMARKERS; SCHIZOPHRENIA; COMPREHENSION; ACTIVATION; ATTENTION; MODEL;
D O I
10.1016/j.biopsycho.2017.04.003
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
An overly negative self-schema is a proposed cognitive mechanism of major depressive disorder (MDD). Self - schema one's core conception of self, including how strongly one believes one possesses various characteristics - is part of semantic memory (SM), our knowledge about concepts and their relationships. We used the N400 event-related potential (ERP) elicited by meaningful stimuli, and reduced by greater association of the stimulus with preceding context to measure association strength between self-concept and positive, negative, and neutral characteristics in SM. ERPs were recorded from MDD patients = 16) and controls (n = 16) who viewed trials comprising a self-referential phrase followed by a positive, negative, or neutral adjective. Participants' task was to indicate via button-press whether or not they felt each adjective described themselves. Controls endorsed more positive adjectives than did MDD patients, but the opposite was true for negative adjectives. Patients had smaller N400s than controls specifically for negative adjectives, suggesting that MDD is associated with stronger than normal functional neural links between self-concept and negative characteristics in SM.
引用
收藏
页码:41 / 47
页数:7
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