Recent developments and future directions in computational genomics

被引：45

作者：

Tsoka, S ^{[1
]}

Ouzounis, CA ^{[1
]}

机构：

[1] EMBL, European Bioinformat Inst, Computat Gen Grp, Res Programme,Cambridge Outstn, Cambridge CB10 1SD, England

来源：

FEBS LETTERS | 2000年 / 480卷 / 01期

基金：

英国医学研究理事会;

关键词：

genomics; bioinformatics; algorithm; molecular biology database; genomic context; systems modelling; knowledge representation;

D O I：

10.1016/S0014-5793(00)01776-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computational genomics is a subfield of computational biology that deals with the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent properties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approaches that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：42 / 48

页数：7

共 107 条

[41] The relationship between protein structure and function: a comprehensive survey with application to the yeast genome [J].