Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile

被引：7

作者：

Lupo, Maria Giovanna ^{[1
]}

Arcidiacono, Diletta ^{[2
]}

Zaramella, Alice ^{[3
,4
]}

Fimiani, Fabio ^{[5
]}

Calabro, Paolo ^{[5
]}

Cefalu, Angelo Baldassare ^{[6
]}

Averna, Maurizio ^{[6
]}

D'Erasmo, Laura ^{[7
]}

Arca, Marcello ^{[7
]}

De Martin, Sara ^{[1
]}

Zambon, Alberto ^{[8
]}

Ferri, Nicola ^{[1
]}

机构：

[1] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Largo Egidio Meneghetti 2, I-35131 Padua, Italy

[2] Veneto Inst Oncol IOV IRCCS, Digest Endoscopy Unit, Padua, Italy

[3] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

[4] Ist Oncol Veneto IOV IRCCS, Padua, Italy

[5] Univ Campania Luigi Vanvitelli, Caserta Dept Translat Med Sci, AORN St Anna & San Sebastiano, Naples, Italy

[6] Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, Palermo, Italy

[7] Sapienza Univ Rome, Dept Translat & Precis Med, Rome, Italy

[8] Univ Padua, Dept Med, Padua, Italy

来源：

ATHEROSCLEROSIS PLUS | 2021年 / 43卷

关键词：

Lomitapide; pcsk9; lp(a); Familial hypercholesterolemia; TRANSFER PROTEIN INHIBITOR; EFFICACY; SAFETY;

D O I：

10.1016/j.athplu.2021.05.001

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：7 / 9

页数：3

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