Minireview: Update on Incretin Biology: Focus on Glucagon-Like Peptide-1

被引：103
作者：
Brubaker, Patricia L. [1 ,2 ]
机构：
[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada
来源：
ENDOCRINOLOGY | 2010年 / 151卷 / 05期
关键词：
TYPE-2; DIABETES-MELLITUS; BETA-CELL REGENERATION; ENTEROENDOCRINE L-CELL; GLYCEMIC CONTROL; ANIMAL-MODEL; NOD MICE; RECEPTOR; SECRETION; GLUCOSE; EXENDIN-4;
D O I：
10.1210/en.2010-0115
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The incretin hormone, glucagon-like peptide-1 (GLP-1), is now being used in the clinic to enhance insulin secretionandreducebodyweight in patients with type 2 diabetes. Althoughmuchis already knownabout the biology of GLP-1, muchremains tobeunderstood. Hence, this review will consider recent findings related to the potential for enhancing endogenous levels of GLP-1 through selective use of secretagogues and the beneficial cardiovascular, neuroprotective, and immunomodulatory effects of GLP-1, as well as the possible effects of GLP-1 to enhance beta-cell growth and/ or to induce pancreatitis or thyroid cancer. Finally, the potential for molecular medicine to enhance the success of GLP-1 therapy in the clinic is considered. A better understanding of the fundamental biology of GLP-1 may lead to new therapeutic modalities for the clinical use of this intestinal hormone. (Endocrinology 151: 1984-1989, 2010)
引用
收藏
页码：1984 / 1989
页数：6
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