Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

被引：10
|
作者：
Xiao, Guizhi [1 ]
Fang, Hao [1 ]
Xing, Chengguo [2 ]
Xu, Wenfang [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China
[2] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Apoptosis; Bcl-2; structure; function; inhibitors; anti-tumor; EFFICIENTLY INDUCES APOPTOSIS; ENDOPLASMIC-RETICULUM CA2+; SMALL-MOLECULE INHIBITORS; ANTIAPOPTOTIC BCL-2; BH3; DOMAIN; ORGANIC-COMPOUND; CANCER; BAX; MEMBERS; ANTISENSE;
D O I：
10.2174/138955709791012238
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
引用
收藏
页码：1596 / 1604
页数：9
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