Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

被引：10

作者：

Xiao, Guizhi ^{[1
]}

Fang, Hao ^{[1
]}

Xing, Chengguo ^{[2
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China

[2] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Apoptosis; Bcl-2; structure; function; inhibitors; anti-tumor; EFFICIENTLY INDUCES APOPTOSIS; ENDOPLASMIC-RETICULUM CA2+; SMALL-MOLECULE INHIBITORS; ANTIAPOPTOTIC BCL-2; BH3; DOMAIN; ORGANIC-COMPOUND; CANCER; BAX; MEMBERS; ANTISENSE;

D O I：

10.2174/138955709791012238

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.

引用

页码：1596 / 1604

页数：9

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