Progress in rigid polysaccharide-based nanocomposites with therapeutic functions

被引:56
|
作者
Liu, Qingye [1 ,2 ]
Duan, Bingchao [1 ]
Xu, Xiaojuan [1 ]
Zhang, Lina [1 ]
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[2] North Univ China, Coll Chem & Environm Engn, Taiyuan 030051, Shanxi, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
TRIPLE-HELICAL POLYSACCHARIDE; WALLED CARBON NANOTUBES; RAW; 264.7; MACROPHAGES; BRANCHED BETA-GLUCAN; YEAST-CELL WALL; SIZE-EXCLUSION CHROMATOGRAPHY; CAPPED GOLD NANOPARTICLES; ACTIVATED PROTEIN-KINASES; ONE-DIMENSIONAL HOST; SINGLE-STRANDED RNA;
D O I
10.1039/c7tb01065f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Polysaccharides are naturally occurring biological macromolecules that are envisaged as promising substitutes of non-degradable polymers due to their outstanding inherent properties of biodegradability, biocompatibility, low-cost, and availability. Their utilization in the development of nanostructured hybrid materials has numerous advantages in theranostics, the integrated approach of therapeutics and diagnostics. In particular, some rigid polysaccharides occur in nature, which can self-assemble into ordered hierarchical structures, facilitating the controllable fabrication of various nanocomposites. These rigid polysaccharides, including Lentinan, Curdlan, Schizophyllan, Scleroglucan, Auricularian, and yeast glucan, possess the linear beta-(1 -> 3)-D-glucan as the backbone with or without beta-(1 -> 6)-linked glucose as the branch, having diverse biological activities. This review focuses on the incorporation of nanoparticles, such as gold (AuNPs), silver (AgNPs), selenium (SeNPs), silica, carbon nanotubes, homo-polynucleotides, bio-imaging probes, and drugs, into different rigid polysaccharide matrices through self-assembly and summarizes their biological functions as well as the correlation to their conformations. Additionally, we addressed the use of the as-engineered polysaccharide nanocomposites as effective therapeutic agents, and the challenges or ambiguity issues concerning further practical clinic therapeutic applications.
引用
收藏
页码:5690 / 5713
页数:24
相关论文
共 50 条
  • [31] Polysaccharide-based nanoparticles for theranostic nanomedicine
    Swierczewska, M.
    Han, H. S.
    Kim, K.
    Park, J. H.
    Lee, S.
    ADVANCED DRUG DELIVERY REVIEWS, 2016, 99 : 70 - 84
  • [32] Polysaccharide-based Nanoparticles for Gene Delivery
    Huh, Myung Sook
    Lee, Eun Jung
    Koo, Heebeom
    Yhee, Ji Young
    Oh, Keun Sang
    Son, Sohee
    Lee, Sojin
    Kim, Sun Hwa
    Kwon, Ick Chan
    Kim, Kwangmeyung
    TOPICS IN CURRENT CHEMISTRY, 2017, 375 (02)
  • [33] Polysaccharide-based hydrogels for cartilage regeneration
    Chen, Ning
    Li, Sidi
    Miao, Congrui
    Zhao, Qin
    Dong, Jinlei
    Li, Lianxin
    Li, Ci
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12
  • [34] Polysaccharide-based Nanoparticles for Gene Delivery
    Myung Sook Huh
    Eun Jung Lee
    Heebeom Koo
    Ji Young Yhee
    Keun Sang Oh
    Sohee Son
    Sojin Lee
    Sun Hwa Kim
    Ick Chan Kwon
    Kwangmeyung Kim
    Topics in Current Chemistry, 2017, 375
  • [35] Biocompatible polysaccharide-based electrorheological suspensions
    Sung, JH
    Choi, HJ
    JOURNAL OF MACROMOLECULAR SCIENCE-PHYSICS, 2005, B44 (04): : 573 - 581
  • [36] Polysaccharide-based nucleic acid nanoformulations
    Raemdonck, Koen
    Martens, Thomas F.
    Braeckmans, Kevin
    Demeester, Jo
    De Smedt, Stefaan C.
    ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (09) : 1123 - 1147
  • [37] Polysaccharide-based chiral LC columns
    Yashima, E
    Yamamoto, C
    Okamoto, Y
    SYNLETT, 1998, (04) : 344 - +
  • [38] Polysaccharide-Based Transdermal Drug Delivery
    Li, Jingyuan
    Xiang, Hong
    Zhang, Qian
    Miao, Xiaoqing
    PHARMACEUTICALS, 2022, 15 (05)
  • [39] Polysaccharide-based antibacterial coating technologies
    Ruan, Hengzhi
    Aulova, Alexandra
    Ghai, Viney
    Pandit, Santosh
    Lovmar, Martin
    Mijakovic, Ivan
    Kadar, Roland
    ACTA BIOMATERIALIA, 2023, 168 : 42 - 77
  • [40] Advances in polysaccharide-based antibacterial materials
    He, Meng
    Huang, Yujia
    Wang, Jinhua
    Chen, Zitong
    Xie, Jinshuo
    Cui, Zhicheng
    Xu, Dingfeng
    Zhang, Xinjiang
    Yao, Wei
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 308