Cellular sources of tissue factor in endotoxemia and sepsis

被引：104
作者：
Pawlinski, Rafal [1 ]
Mackman, Nigel [1 ]
机构：
[1] Univ N Carolina, Div Hematol & Oncol, Dept Med, Chapel Hill, NC 27516 USA
来源：
THROMBOSIS RESEARCH | 2010年 / 125卷
基金：
美国国家卫生研究院;
关键词：
Tissue factor; Cell type; Sepsis; Endotoxemia; Disseminated intravascular coagulation; FACTOR PATHWAY INHIBITOR; FACTOR MESSENGER-RNA; FACTOR GENE-EXPRESSION; TUMOR-NECROSIS-FACTOR; EXTRINSIC PATHWAY; WHOLE-BLOOD; IN-VIVO; COAGULATION; ACTIVATION; THROMBOMODULIN;
D O I：
10.1016/j.thromres.2010.01.042
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S70 / S73
页数：4
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