Bradykinin antagonists: new opportunities

被引：50
作者：
Bock, MG [1 ]
Longmore, J
机构：
[1] Merck Res Labs, W Point, PA 19486 USA
[2] Merck Sharp & Dohme Ltd, Res Labs, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期
关键词：
D O I：
10.1016/S1367-5931(00)00107-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pro-inflammatory, pain producing, and cardiovascular effects of bradykinin B-2 receptor activation are well characterized. Bradykinin B-1 receptors also produce inflammation and pain. Therefore, antagonists are expected to be anti-inflammatory/analgesic drugs. Other exploitable clinical opportunities may exist. The newly discovered non-peptide B-2 receptor antagonists and the equivalent B-1 receptor pharmacological agents, which are in the pipeline, are suitable preclinical tools to properly evaluate potential utilities.
引用
收藏
页码：401 / 406
页数：6
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