Formulation, characterization, and evaluation of ligand-conjugated biodegradable quercetin nanoparticles for active targeting

被引：27

作者：

Gupta, Anshita ^{[1
]}

Kaur, Chanchal Deep ^{[1
,2
]}

Saraf, Shailendra ^{[1
]}

Saraf, Swarnlata ^{[1
]}

机构：

[1] Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, Chhattisgarh, India

[2] Shri Rawatpura Sarkar Inst Pharm, Kumhari, Chhattisgarh, India

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 03期

关键词：

folate; mannose; MTT assay; nanoparticles; response surface methodology; targeted drug delivery; NANOSTRUCTURED LIPID CARRIERS; LOADED PLGA NANOPARTICLES; DRUG-DELIVERY SYSTEM; POLYMERIC NANOPARTICLES; DESIGN; OPTIMIZATION; NLC; CURCUMIN; SKIN;

D O I：

10.3109/21691401.2015.1008503

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and in vitro release studies were also performed. The MTT assay was performed against two different cell lines, to measure their anticancer potentials and their targeting ability. The study thus reveals that MA-Qu-PLGA and FA-Qu-PLGA nanoparticles (NPs) can be used as effective drug delivery systems for skin cancer treatment encompassing natural drugs.

引用

页码：960 / 970

页数：11

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