A 'one pot' microwave-mediated synthesis of the basic canthine skeleton:: expedient access to unnatural β-carboline alkaloids

被引：49

作者：

Lindsley, CW ^{[1
]}

Wisnoski, DD ^{[1
]}

Wang, Y ^{[1
]}

Leister, WH ^{[1
]}

Zhao, ZJ ^{[1
]}

机构：

[1] Merck Res Labs, Technol Enabled Synth Grp, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(03)01019-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a 'one pot' microwave reaction, an acyl hydrazide-tethered indole underwent a 3-component condensation to form a triazine followed by an inverse-electron demand Diels-Alder reaction and subsequent chelotropic expulsion of N, to deliver novel. unnatural beta-carboline alkaloids in good isolated yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4495 / 4498

页数：4

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