Proliferative capacity exhibited by human liver-resident CD49a+CD25+NK cells

被引：20

作者：

Martrus, Gloria ^{[1
]}

Kautz, Tobias ^{[1
]}

Lunemann, Sebastian ^{[1
]}

Richert, Laura ^{[1
,2
,3
]}

Glau, Laura ^{[4
]}

Salzberger, Wilhelm ^{[1
]}

Goebels, Hanna ^{[1
]}

Langeneckert, Annika ^{[1
]}

Hess, Leonard ^{[1
]}

Poch, Tobias ^{[5
]}

Schramm, Christoph ^{[5
]}

Oldhafer, Karl J. ^{[6
]}

Koch, Martina ^{[7
]}

Tolosa, Eva ^{[4
]}

Nashan, Bjoern ^{[7
]}

Altfeld, Marcus ^{[1
]}

机构：

[1] Leibniz Inst Expt Virol, Heinrich Pette Inst, Hamburg, Germany

[2] Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, Team SISTM,UMR1219, Bordeaux, France

[3] INRIA, Bordeaux, France

[4] Univ Med Ctr Hamburg Eppendorf, Dept Immunol, Hamburg, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany

[6] Semmelweis Univ Med, Asklepios Hosp Barmbek, Dept Gen & Abdominal Surg, Asklepios Campus, Hamburg, Germany

[7] Univ Med Ctr Hamburg Eppendorf, Dept Hepatobiliary & Transplant Surg, Hamburg, Germany

来源：

PLOS ONE | 2017年 / 12卷 / 08期

关键词：

HEMATOPOIETIC STEM-CELLS; CHRONIC HEPATITIS-C; LAMININ COLLAGEN RECEPTOR; NATURAL-KILLER-CELLS; NK CELLS; DIFFERENTIAL EXPRESSION; EXTRACELLULAR-MATRIX; ADAPTIVE IMMUNITY; TISSUE-RESIDENT; T-CELLS;

D O I：

10.1371/journal.pone.0182532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recruitment and retention of Natural Killer (NK) cells in the liver are thought to play an important role during hepatotropic infections and liver cirrhosis. The aims of this study were to determine differences between liver-derived and peripheral blood-derived NK cells in the context of liver inflammation and cirrhosis. We conducted a prospective dual-center cross-sectional study in patients undergoing liver transplantation or tumor-free liver resections, in which both liver tissue and peripheral blood samples were obtained from each consenting study participants. Intrahepatic lymphocytes and PBMCs were stained, fixed and analyzed by flow cytometry. Our results showed that, within cirrhotic liver samples, intrahepatic NK cells were particularly enriched for CD49a+ NK cells when compared to tumor-free liver resection samples. CD49a+ liver-derived NK cells included populations of cells expressing CD25, CD34 and CXCR3. Moreover, CD49a+ CD25+ liver-derived NK cells exhibited high proliferative capacity in vitro in response to low doses of IL-2. Our study identified a specific subset of CD49a+ CD25+ NK cells in cirrhotic livers bearing functional features of proliferation.

引用

页数：18

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