Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma

被引：10

作者：

Zhang, Yujie ^{[1
]}

Wang, Yanyan ^{[2
]}

Ying, Liwei ^{[1
]}

Tao, Sifeng ^{[2
]}

Shi, Mingmin ^{[1
]}

Lin, Peng ^{[1
]}

Wang, Yangxin ^{[1
]}

Han, Bin ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped Surg, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Oncol Surg, Hangzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

N6-methyladenosine (m(6)A); molecular mechanisms; osteosarcoma; biomarker; therapeutic target; N-6-METHYLADENOSINE MODIFICATION; TUMOR PROGRESSION; RNA METHYLATION; CANCER; MICROENVIRONMENT; TUMORIGENESIS; METASTASIS; EXPRESSION;

D O I：

10.3389/fonc.2021.683768

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma is the most common primary bone malignancy, typically occurring in childhood or adolescence. Unfortunately, the clinical outcomes of patients with osteosarcoma are usually poor because of the aggressive nature of this disease and few treatment advances in the past four decades. N6-methyladenosine (m(6)A) is one of the most extensive forms of RNA modification in eukaryotes found both in coding and non-coding RNAs. Accumulating evidence suggests that m(6)A-related factors are dysregulated in multiple osteosarcoma processes. In this review, we highlight m(6)A modification implicated in osteosarcoma, describing its pathophysiological role and molecular mechanism, as well as future research trends and potential clinical application in osteosarcoma.

引用

页数：9

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