Superior Appetite Hormone Profile After Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding

被引：80
作者：
Bose, Mousumi [1 ,2 ]
Machineni, Sriram [1 ]
Olivan, Blanca [1 ]
Teixeira, Julio [2 ,3 ]
McGinty, James J. [2 ,3 ]
Bawa, Baani [1 ]
Koshy, Ninan [2 ,3 ]
Colarusso, Antonia [1 ]
Laferrere, Blandine [1 ,2 ,4 ]
机构：
[1] St Lukes Roosevelt Hosp, New York Obes Res Ctr, New York, NY USA
[2] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
[3] St Lukes Roosevelt Hosp, Dept Surg, Ctr Bariatr Surg & Metab Dis, New York, NY USA
[4] St Lukes Roosevelt Hosp, Dept Med, Div Endocrinol Diabet & Nutr, New York, NY USA
来源：
OBESITY | 2010年 / 18卷 / 06期
关键词：
GLUCAGON-LIKE PEPTIDE-1; PLASMA GHRELIN LEVELS; FOOD-INTAKE; GUT HORMONE; BODY-WEIGHT; BARIATRIC SURGERY; INCRETIN LEVELS; OBESE-PATIENTS; SERUM LEPTIN; GLUCOSE;
D O I：
10.1038/oby.2009.473
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight-and age-matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY 3-36 (PYY 3-36), ghrelin, glucagon-like peptide-1 (GLP-1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose-stimulated GLP-1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP-1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP-1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.
引用
收藏
页码：1085 / 1091
页数：7
相关论文
共 47 条
  • [1] The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    Abbott, CR
    Monteiro, M
    Small, CJ
    Sajedi, A
    Smith, KL
    Parkinson, JRC
    Ghatei, MA
    Bloom, SR
    [J]. BRAIN RESEARCH, 2005, 1044 (01) : 127 - 131
  • [2] Laparoscopic adjustable gastric banding versus Roux-en-Y gastric bypass: 5-year results of a prospective randomized trial
    Angrisani, Luigi
    Lorenzo, Michele
    Borrelli, Vincenzo
    [J]. SURGERY FOR OBESITY AND RELATED DISEASES, 2007, 3 (02) : 127 - 132
  • [3] PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
    Batterham, Rachel L.
    ffytche, Dominic H.
    Rosenthal, J. Miranda
    Zelaya, Fernando O.
    Barker, Gareth J.
    Withers, Dominic J.
    Williams, Steven C. R.
    [J]. NATURE, 2007, 450 (7166) : 106 - +
  • [4] Gut hormone PYY3-36 physiologically inhibits food intake
    Batterham, RL
    Cowley, MA
    Small, CJ
    Herzog, H
    Cohen, MA
    Dakin, CL
    Wren, AM
    Brynes, AE
    Low, MJ
    Ghatei, MA
    Cone, RD
    Bloom, SR
    [J]. NATURE, 2002, 418 (6898) : 650 - 654
  • [5] Inhibition of food intake in obese subjects by peptide YY3-36
    Batterham, RL
    Cohen, MA
    Ellis, SM
    Le Roux, CW
    Withers, DJ
    Frost, GS
    Ghatei, MA
    Bloom, SR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) : 941 - 948
  • [6] Bariatric surgery: A systematic review and meta-analysis
    Buchwald, H
    Avidor, Y
    Braunwald, E
    Jensen, MD
    Pories, W
    Fahrbach, K
    Schoelles, K
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (14): : 1724 - 1737
  • [7] Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects
    Chapman, Ian
    Parker, Barbara
    Doran, Selena
    Feinle-Bisset, Christine
    Wishart, Judith
    Lush, Caineron W.
    Chen, Kim
    LaCerte, Carl
    Burns, Colleen
    McKay, Robyn
    Weyer, Christian
    Horowitz, Michael
    [J]. OBESITY, 2007, 15 (05) : 1179 - 1186
  • [8] Gastrointestinal regulation of food intake
    Cummings, David E.
    Overduin, Joost
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) : 13 - 23
  • [9] A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    Cummings, DE
    Purnell, JQ
    Frayo, RS
    Schmidova, K
    Wisse, BE
    Weigle, DS
    [J]. DIABETES, 2001, 50 (08) : 1714 - 1719
  • [10] Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
    Cummings, DE
    Weigle, DS
    Frayo, RS
    Breen, PA
    Ma, MK
    Dellinger, EP
    Purnell, JQ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (21) : 1623 - 1630
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