Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis

被引：21
作者：
Zhao, Yanxin [1 ]
Tan, Wei [2 ]
Sheng, Wenhua [1 ]
Li, Xiaohong [1 ]
机构：
[1] Shandong Univ, Jinan Cent Hosp, Dept Neurol, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China
[2] Shandong Univ, Jinan Cent Hosp, Dept Gen Surg, Jinan 250013, Shandong, Peoples R China
来源：
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2016年 / 31卷 / 02期
关键词：
Alzheimer's disease; micro RNA; differentially expressed genes; functional cluster; target genes; regulatory network; EXPRESSION; MECHANISMS; BRAIN; MIRNA; PROTEOSTASIS; FEATURES; DATABASE;
D O I：
10.1177/1533317515588181
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: This study aimed to explore the biomarkers of Alzheimer's disease (AD). Methods: The microarray data of GSE16759 were from the expression profile samples of 4 parietal lobe tissues from patients with AD and 4 ones from age-matched control participants. The differentially expressed micro RNAs (miRNAs) and genes (DEGs) underwent hierarchical clustering and function analysis followed by target genes prediction. Finally, DEGs were mapped to the target genes to construct miRNA-regulated networks. Results: A total of 427 DEGs were obtained and clustered into 5 functions. After DEGs were mapped to the predicted target genes, 313 regulatory pairs were established. The target genes SEC22 vesicle trafficking protein homolog B (SEC22B) and SEC63 homolog (SEC63) regulated by miRNA-206, RAB10, member RAS oncogene family (RAB10) regulated by miRNA-655, and fms-related tyrosine kinase 1 (FLT1) regulated by miRNA-30e-3p and miRNA-369-3p were involved in the biological processes of protein transport and regulation of cell motion. Conclusion: The target genes SEC22B, RAB10, and FLT1 may be potential biomarkers of AD.
引用
收藏
页码：163 / 168
页数：6
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