2,4-Diaminotriazines as anti-infective agents

被引：0

作者：

De, Suparna S. ^{[1
]}

Vogalu, Siva K. ^{[2
]}

Ansari, Nazima ^{[1
]}

Patil, Rajendra ^{[3
]}

Sriram, Dharmarajan ^{[2
]}

Degani, Mariam S. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, NP Marg, Mumbai 400019, Maharashtra, India

[2] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, India

[3] Savitribai Phule Pune Univ, Dept Biotechnol, Pune 411007, Maharashtra, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2020年 / 97卷 / 08期

关键词：

2,4-Diaminotriazine; tuberculosis; leishmaniasis; cytotoxicity; BIOLOGICAL EVALUATION; DIHYDROFOLATE-REDUCTASE; DERIVATIVES; INHIBITORS; TRIAZINES; SCAFFOLD;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triazines are scaffolds of interest to medicinal chemists as they have a wide variety of pharmacological activities. Molecules with the triazine moiety have been explored extensively for their anti-infective potential. In this paper, we report a series of 2,4-diaminotriazine derivatives which have been designed and synthesized to explore their DHFR inhibiting potential in various micro-organisms. These molecules have not only been evaluated for their anti-tuberculosis activity, but also for their E. coli, S. aureus and their anti-leishmanial potential. The series has moderate activity vs E. coli and S. aureus, low activity against tuberculosis and good potential for leishmaniasis, from the preliminary results.

引用

页码：1211 / 1215

页数：5

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