New developments implicating IL-21 in autoimmune disease

被引：58

作者：

Ren, Heather M. ^{[1
,2
]}

Lukacher, Aron E. ^{[2
]}

Rahman, Ziaur S. M. ^{[2
]}

Olsen, Nancy J. ^{[3
]}

机构：

[1] Penn State Coll Med, MD PhD Med Scientist Training Program, Hershey, PA 17033 USA

[2] Penn State Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

[3] Penn State MS Hershey Med Ctr, Dept Med, Devis Rheumatol, Hershey, PA 17033 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2021年 / 122卷

关键词：

Autoimmunity; Interleukin (IL)-21; CD4 T cells; CD8 T cells; Resident memory; CD8(+) T-CELLS; ANTI-IL-21; MONOCLONAL-ANTIBODY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FIBROBLAST-LIKE SYNOVIOCYTES; CENTRAL-NERVOUS-SYSTEM; COMPLEX CLASS-I; RHEUMATOID-ARTHRITIS; INTERLEUKIN-21; RECEPTOR; PEMPHIGUS-VULGARIS; SJOGRENS-SYNDROME;

D O I：

10.1016/j.jaut.2021.102689

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated interleukin (IL)-21 is a common finding in the tissues and/or sera of patients with autoimmune disease. CD4 T cells are the primary producers of IL-21; often the IL-21 producing CD4 T cells will express molecules associated with follicular helper cells (TFH). Recent work has shown that the CD4 T cell-derived IL-21 is able to promote effector functions and memory differentiation of CD8 T cells in chronic infections and cancer. Autoimmunity has similarities to chronic infections and cancer. However, CD4 T cell-derived IL-21:IL21R signaling in CD8 T cells has not been fully appreciated in the context of autoimmunity. In this review, we assess the current knowledge regarding CD4 T cell-derived IL-21 and IL21R signaling within CD8 T cells and evaluate what implications it has within several autoimmune diseases including systemic lupus erythematous, rheumatoid arthritis, juvenile idiopathic arthritis, type 1 diabetes mellitus, psoriasis, Sjo center dot gren's syndrome, vitiligo, antiphospholipid syndrome, pemphigus, and giant cell arteritis.

引用

页数：12

共 129 条

[1] Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes [J].

Abdelsamed, Hossam A. ;

Zebley, Caitlin C. ;

Hai Nguyen ;

Rutishauser, Rachel L. ;

Fan, Yiping ;

Ghoneim, Hazem E. ;

Crawford, Jeremy Chase ;

Alfei, Francesca ;

Alli, Shanta ;

Ribeiro, Susan Pereira ;

Castellaw, Ashley H. ;

McGargill, Maureen A. ;

Jin, Hongjian ;

Boi, Shannon K. ;

Speake, Cate ;

Serti, Elisavet ;

Turka, Laurence A. ;

Busch, Michael E. ;

Stone, Mars ;

Deeks, Steven G. ;

Sekaly, Rafick-Pierre ;

Zehn, Dietmar ;

James, Eddie A. ;

Nepom, Gerald T. ;

Youngblood, Ben .

NATURE IMMUNOLOGY, 2020, 21 (05) :578-+

[2] AUTOANTIBODIES AGAINST A NOVEL EPITHELIAL CADHERIN IN PEMPHIGUS-VULGARIS, A DISEASE OF CELL-ADHESION [J].

AMAGAI, M ;

KLAUSKOVTUN, V ;

STANLEY, JR .

CELL, 1991, 67 (05) :869-877

[3]

Amer A., 2019, J CLIN DERMATOL THER, V5, P039, DOI [DOI 10.24966/CDT-8771/100039, 10.24966/CDT-8771/100039]

[4] Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome [J].

Benagiano, Marisa ;

Borghi, Maria Orietta ;

Romagnoli, Jacopo ;

Mahler, Michael ;

Della Bella, Chiara ;

Grassi, Alessia ;

Capitani, Nagaja ;

Emmi, Giacomo ;

Troilo, Arianna ;

Silvestri, Elena ;

Emmi, Lorenzo ;

Alnwaisri, Heba ;

Bitetti, Jacopo ;

Tapinassi, Simona ;

Prisco, Domenico ;

Baldari, Cosima Tatiana ;

Meroni, Pier Luigi ;

D'Elios, Mario Milco .

HAEMATOLOGICA, 2019, 104 (12) :2519-2527

[5] Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study [J].

Bhatia, Shailender ;

Curti, Brendan ;

Ernstoff, Marc S. ;

Gordon, Michael ;

Heath, Elisabeth I. ;

Miller, Wilson H., Jr. ;

Puzanov, Igor ;

Quinn, David I. ;

Flaig, Thomas W. ;

VanVeldhuizen, Peter ;

Byrnes-Blake, Kelly ;

Freeman, Jeremy A. ;

Bittner, Rachel ;

Hunder, Naomi ;

Souza, Sonia ;

Thompson, John A. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2014, 2

[6] PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21 [J].

Bocharnikov, Alexandra, V ;

Keegan, Joshua ;

Wacleche, Vanessa S. ;

Cao, Ye ;

Fonseka, Chamith Y. ;

Wang, Guoxing ;

Muise, Eric S. ;

Zhang, Kelvin X. ;

Arazi, Arnon ;

Keras, Gregory ;

Li, Zhihan J. ;

Qu, Yujie ;

Gurish, Michael F. ;

Petri, Michelle ;

Guyon, Jill P. ;

Putterman, Chaim ;

Wofsy, David ;

James, Judith A. ;

Guthridge, Joel M. ;

Diamond, Betty ;

Anolik, Jennifer H. ;

Mackey, Matthew F. ;

Alves, Stephen E. ;

Nigrovic, Peter A. ;

Costenbader, Karen H. ;

Brenner, Michael B. ;

Lederer, James A. ;

Rao, Deepak A. .

JCI INSIGHT, 2019, 4 (20)

[7] Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3 [J].

Boniface, Katia ;

Jacquemin, Clement ;

Darrigade, Anne-Sophie ;

Dessarthe, Benoit ;

Martins, Christina ;

Boukhedouni, Nesrine ;

Vernisse, Charlotte ;

Grasseau, Alexis ;

Thiolat, Denis ;

Rambert, Jerome ;

Lucchese, Fabienne ;

Bertolotti, Antoine ;

Ezzedine, Khaled ;

Taieb, Alain ;

Seneschal, Julien .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (02) :355-364

[8] A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice [J].

Bubier, Jason A. ;

Sproule, Thomas J. ;

Foreman, Oded ;

Spolski, Rosanne ;

Shaffer, Daniel J. ;

Morse, Herbert C., III ;

Leonard, Warren J. ;

Roopenian, Derry C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (05) :1518-1523

[9] An Integrated Analysis of the Safety of Tofacitinib in Psoriatic Arthritis across Phase III and Long-Term Extension Studies with Comparison to Real-World Observational Data [J].

Burmester, Gerd R. ;

Curtis, Jeffrey R. ;

Yun, Huifeng ;

FitzGerald, Oliver ;

Winthrop, Kevin L. ;

Azevedo, Valderilio F. ;

Rigby, William F. C. ;

Kanik, Keith S. ;

Wang, Cunshan ;

Biswas, Pinaki ;

Jones, Thomas ;

Palmetto, Niki ;

Hendrikx, Thijs ;

Menon, Sujatha ;

Rojo, Ricardo .

DRUG SAFETY, 2020, 43 (04) :379-392

[10] T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes [J].

Burrack, Adam L. ;

Martinov, Tijana ;

Fife, Brian T. .

FRONTIERS IN ENDOCRINOLOGY, 2017, 8

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