hrHPV E5 oncoprotein: immune evasion and related immunotherapies

被引：63

作者：

de Freitas, Antonio Carlos ^{[1
]}

Araujo de Oliveira, Talita Helena ^{[1
]}

Barros, Marconi Rego, Jr. ^{[1
]}

Venuti, Aldo ^{[2
]}

机构：

[1] Univ Fed Pernambuco, Dept Genet, Ctr Biol Sci, Lab Mol Studies & Expt Therapy LEMTE, Av Prof Moraes Rego 1235,Cidade Univ, BR-50670901 Recife, PE, Brazil

[2] Regina Elena Inst Canc Res, Adv Diagnost & Technol Innovat, UOSD Tumor Immunol & Immunotherapy Unit, HPV Unit,Dept Res, Via Elio Chianesi 53, I-00144 Rome, Italy

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2017年 / 36卷

关键词：

Human Papillomavirus; HPV-related cancer; E5; oncoprotein; Immune response modulation; HPV immune evasion; Immunotherapy; HUMAN-PAPILLOMAVIRUS TYPE-16; NF-KAPPA-B; DENDRITIC CELL VACCINATION; CERVICAL-CANCER PATIENTS; HPV16; E5; CLASS-I; NK CELLS; INTERFERON-LAMBDA; GROWTH-FACTOR; UP-REGULATION;

D O I：

10.1186/s13046-017-0541-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene is responsible for modulation of several immune mechanisms, including antigen presentation and inflammatory pathways. Moreover, E5 was suggested as a promising therapeutic target, since there is still no effective medical therapy for the treatment of HPV-related pre-neoplasia and cancer. Indeed, several studies have shown good prospective for E5 immunotherapy, suggesting that it could be applied for the treatment of pre-cancerous lesions. Thus, insofar as the majority of cervical, oropharyngeal and anal cancers are caused by high-risk HPV (hrHPV), mainly by HPV16, the aim of this review is to discuss the immune pathways interfered by E5 oncoprotein of hrHPV highlighting the various aspects of the potential immunotherapeutic approaches.

引用

页数：15

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