Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle

被引：16

作者：

Gonzalez-Hedstrom, Daniel ^{[1
,2
]}

Priego, Teresa ^{[3
]}

Amor, Sara ^{[1
]}

de la Fuente-Fernandez, Maria ^{[1
]}

Martin, Ana Isabel ^{[3
]}

Lopez-Calderon, Asuncion ^{[3
]}

Inarejos-Garcia, Antonio Manuel ^{[2
]}

Garcia-Villalon, Angel Luis ^{[1
]}

Granado, Miriam ^{[1
,4
]}

机构：

[1] Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain

[2] Pharmact Biotech Prod SL Parque Cient Madrid, Ave Doctor Severo Ochoa, Madrid 28049, Spain

[3] Univ Complutense Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain

[4] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 05期

关键词：

aging; adipose tissue; skeletal muscle; sarcopenia; insulin resistance; olive leaf extract; inflammation; oxidative stress; MYOGENIC REGULATORY FACTORS; MESSENGER-RNA EXPRESSION; LIPID-ACCUMULATION; OXIDATIVE STRESS; RESISTANCE; AGE; MYOSTATIN; INFLAMMATION; IMPROVES; BROWN;

D O I：

10.3390/antiox10050737

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-gamma in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-alpha in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.

引用

页数：18

共 22 条

[21] Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice
Zhang, Xinmei
Xu, Aimin
Chung, Sookja K.
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DIABETES, 2011, 60 (02) : 486 - 495
[22] RETRACTED: L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity (Retracted article. See vol. 61, pg. 253, 2018)
Prada, P. O.
Hirabara, S. M.
de Souza, C. T.
Schenka, A. A.
Zecchin, H. G.
Vassallo, J.
Velloso, L. A.
Carneiro, E.
Carvalheira, J. B. C.
Curi, R.
Saad, M. J.
DIABETOLOGIA, 2007, 50 (09) : 1949 - 1959

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