Smoking-Related Diffuse Cystic Lung Disease

被引:12
作者
Gupta, Nishant [1 ,2 ]
Colby, Thomas V. [3 ]
Meyer, Cristopher A. [4 ]
McCormack, Francis X. [1 ,2 ]
Wikenheiser-Brokamp, Kathryn A. [5 ,6 ,7 ]
机构
[1] Univ Cincinnati, Div Pulm Crit Care & Sleep Med, 231 Albert Sabin Way,MSB Room 6053,ML 0564, Cincinnati, OH 45267 USA
[2] Vet Affairs Med Ctr, Med Serv, Cincinnati, OH 45267 USA
[3] Mayo Clin Arizona, Dept Lab Med & Pathol, Scottsdale, AZ USA
[4] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA
[5] Cincinnati Childrens Hosp Med Ctr, Div Pulm Biol, Div Pathol & Lab Med, Cincinnati, OH 45229 USA
[6] Cincinnati Childrens Hosp Med Ctr, Div Pulm Biol, Perinatal Inst, Cincinnati, OH 45229 USA
[7] Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH USA
关键词
LYMPHANGIOLEIOMYOMATOSIS DIAGNOSIS; MANAGEMENT; GUIDELINES;
D O I
10.1016/j.chest.2018.02.027
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were referred to our institution with a presumed diagnosis of LAM and who were found instead to have smoking-related injury of the small airways on histopathological analysis. We submit that cigarette smoke-induced small airway injury can present as DCLD on HRCT in a pattern that can mimic LAM. A detailed history of cigarette smoke exposure should be obtained in patients presenting with DCLD, and imaging features should not be used in isolation to establish a firm diagnosis of LAM.
引用
收藏
页码:E31 / E35
页数:5
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