CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice

被引：16

作者：

Zhang, Hui ^{[1
]}

Gong, Quan ^{[1
,2
]}

Li, Jun-hua ^{[3
]}

Kong, Xiao-ling ^{[1
]}

Tian, Li ^{[1
]}

Duan, Li-hua ^{[1
]}

Tong, Jing ^{[1
]}

Song, Fei-fei ^{[1
]}

Fang, Min ^{[1
]}

Zheng, Fang ^{[1
]}

Xiong, Ping ^{[1
]}

Tan, Zheng ^{[1
]}

Gong, Fei-li ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China

[2] Yangtze Univ, Sch Med, Dept Immunol, Jinzhou 434023, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Organ Transplantat, Wuhan 430030, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2010年 / 10卷 / 01期

关键词：

Concanavalin A; CpG ODN; TNF-alpha; IFN-gamma; NF-kappa B; NF-KAPPA-B; CELL-MEDIATED HEPATITIS; DEPENDENT LIVER-INJURY; DNA; ACTIVATION; PROTECTS; DEATH; GAMMA;

D O I：

10.1016/j.intimp.2009.09.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell-mediated hepatic damage plays a key role in the pathogenesis of liver diseases Such as autoimmune hepatitis, viral hepatitis and acute liver failure CpG-containing oligodeoxynucleotides (CpG ODN), a ligand for toll-like receptor (TLR) 9. is widely used as ail immunological adjuvant In the present study. we investigated the effect of CpG ODN on T cell-mediated liver injury in a murine model of concanavalin A (Con A)-induced hepatitis We found that the aminotransferase level was significantly decreased in CpG ODN pretreated mice and the Survival of the mice was markedly prolonged. CpG ODN pretreatment inhibited NF-kappa B DNA binding activity As a result, the systemic/liver levels of TNF-alpha and IFN-gamma were significantly suppressed Furthermore. the activation of inflammatory cells was diminished by CpG ODN pretreatment These results Suggest that CpG ODN pretreatment protects the mice from Con A-induced liver injury via inhibiting hepatocyte apoptosis, inflammation and activation of lymphocytes (C) 2009 Elsevier B V All rights reserved

引用

页码：79 / 85

页数：7

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