WNT Ligand Dependencies in Pancreatic Cancer

被引：38

作者：

Aguilera, Kristina Y. ^{[1
]}

Dawson, David W. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

pancreatic ductal adenocarcinoma; intraductal papillary mucinous neoplasms; RNF43; PORCN; R-spondin; WNT/beta-catenin signaling; WNT7B; FZD5; PATHWAY; TUMOR; GROWTH; TUMORIGENICITY; INHIBITION; MUTATIONS; PORCUPINE; RECEPTOR; SUBTYPES; DISEASE;

D O I：

10.3389/fcell.2021.671022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

WNT signaling promotes the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) through wide-ranging effects on cellular proliferation, survival, differentiation, stemness, and tumor microenvironment. Of therapeutic interest is a genetically defined subset of PDAC known to have increased WNT/beta-catenin transcriptional activity, growth dependency on WNT ligand signaling, and response to pharmacologic inhibitors of the WNT pathway. Here we review mechanisms underlying WNT ligand addiction in pancreatic tumorigenesis, as well as the potential utility of therapeutic approaches that functionally antagonize WNT ligand secretion or frizzled receptor binding.

引用

页数：7

共 71 条

[1] β-Catenin-Independent Roles of Wnt/LRP6 Signaling [J].

Acebron, Sergio P. ;

Niehrs, Christof .

TRENDS IN CELL BIOLOGY, 2016, 26 (12) :956-967

[2] GATA transcription factors integrate Wnt signalling during heart development [J].

Afouda, Boni A. ;

Martin, Jennifer ;

Liu, Fei ;

Ciau-Uitz, Aldo ;

Patient, Roger ;

Hoppler, Stefan .

DEVELOPMENT, 2008, 135 (19) :3185-3190

[3] Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma [J].

Aguirre, Andrew J. ;

Hruban, Ralph H. ;

Raphael, Benjamin J. .

CANCER CELL, 2017, 32 (02) :185-+

[4] WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma [J].

Arensman, M. D. ;

Kovochich, A. N. ;

Kulikauskas, R. M. ;

Lay, A. R. ;

Yang, P-T ;

Li, X. ;

Donahue, T. ;

Major, M. B. ;

Moon, R. T. ;

Chien, A. J. ;

Dawson, D. W. .

ONCOGENE, 2014, 33 (07) :899-908

[5] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[6] R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6 [J].

Binnerts, Minke E. ;

Kim, Kyung-Ah ;

Bright, Jessica M. ;

Patel, Sejal M. ;

Tran, Karolyn ;

Zhou, Mei ;

Leung, John M. ;

Liu, Yi ;

Lomas, Woodrow E., III ;

Dixon, Melissa ;

Hazell, Sophie A. ;

Wagle, Marie ;

Nie, Wen-Sheng ;

Tomasevic, Nenad ;

Williams, Jason ;

Zhan, Xiaoming ;

Levy, Michael D. ;

Funk, Walter D. ;

Abo, Arie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (37) :14700-14705

[7] Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a [J].

Chen, Yii-Shyuan ;

Wu, Rui ;

Yang, Xiaosong ;

Kou, Shuping ;

MacDougald, Ormond A. ;

Yu, Liqing ;

Shi, Hang ;

Xue, Bingzhong .

SCIENTIFIC REPORTS, 2016, 6

[8]

Davis SL, 2020, INVEST NEW DRUG, V38, P821, DOI [10.1007/s10637-019-00824-1, 10.1038/s41564-019-0492-8]

[9] Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma [J].

di Magliano, Marina Pasca ;

Biankin, Andrew V. ;

Heiser, Patrick W. ;

Cano, David A. ;

Gutierrez, Pedro J. A. ;

Deramaudt, Therese ;

Segara, Davendra ;

Dawson, Amanda C. ;

Kench, James G. ;

Henshall, Susan M. ;

Sutherland, Robert L. ;

Dlugosz, Andrzej ;

Rustgi, Anil K. ;

Hebrok, Matthias .

PLOS ONE, 2007, 2 (11)

[10] Leveraging Mechanisms Governing Pancreatic Tumorigenesis To Reduce Pancreatic Cancer Mortality [J].

Donahue, Timothy R. ;

Dawson, David W. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2016, 27 (11) :770-781

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