Laser speckle contrast imaging of collateral blood flow during acute ischemic stroke

被引：101
作者：
Armitage, Glenn A.
Todd, Kathryn G. [2 ]
Shuaib, Ashfaq [3 ]
Winship, Ian R. [1 ,2 ]
机构：
[1] Univ Alberta, Dept Psychiat, Ctr Neurosci, Edmonton, AB T6G 2G3, Canada
[2] Univ Alberta, Dept Psychiat, Neurochem Res Unit, Edmonton, AB T6G 2G3, Canada
[3] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2G3, Canada
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 08期
关键词：
animal models; cerebral blood flow; embolic stroke; focal ischemia; neuroprotection; pial vessels; REPERFUSION; FLOWMETRY; OCCLUSION;
D O I：
10.1038/jcbfm.2010.73
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Collateral vasculature may provide an alternative route for blood flow to reach the ischemic tissue and partially maintain oxygen and nutrient support during ischemic stroke. However, much about the dynamics of stroke-induced collateralization remains unknown. In this study, we used laser speckle contrast imaging to map dynamic changes in collateral blood flow after middle cerebral artery occlusion in rats. We identified extensive anastomatic connections between the anterior and middle cerebral arteries that develop after vessel occlusion and persist for 24 hours. Augmenting blood flow through these persistent yet dynamic anastomatic connections may be an important but relatively unexplored avenue in stroke therapy. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1432-1436; doi: 10.1038/jcbfm.2010.73; published online 2 June 2010
引用
收藏
页码：1432 / 1436
页数：5
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