(Oligo)metastasis as a Spectrum of Disease

被引：27

作者：

Gutiontov, Stanley, I ^{[1
]}

Pitroda, Sean P. ^{[1
]}

Tran, Phuoc T. ^{[2
]}

Weichselbaum, Ralph R. ^{[1
]}

机构：

[1] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

来源：

CANCER RESEARCH | 2021年 / 81卷 / 10期

关键词：

METASTATIC COLORECTAL-CANCER; HEPATIC RESECTION; CELL; SURVIVAL; THERAPY; PEMBROLIZUMAB; ESTABLISHMENT; RADIOTHERAPY; TOMOGRAPHY; RECURRENCE;

D O I：

10.1158/0008-5472.CAN-20-3337

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer metastasis is the leading cause of cancer-related mortality, and most patients with metastases from solid tumors have historically been considered incurable. Here, we discuss the evolution of our understanding of the oligometastatic state with an emphasis on the view that cancer metastasis represents a spectrum of disease. We highlight several recently published prospective clinical trials demonstrating improvements in cancer-specific outcomes with the utilization of metastasis-directed local therapies. We discuss biological aspects of oligometastases, including genetic, epigenetic, and immune determinants of the metastatic spectrum. Finally, we propose future considerations regarding clinical trial design for patients with oligometastatic disease.

引用

页码：2577 / 2583

页数：7

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