Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats

被引：113

作者：

Kasetti, Ramesh Babu ^{[1
]}

Rajasekhar, Maddirala Dilip ^{[1
]}

Kondeti, Vinay Kumar ^{[1
]}

Fatima, Shaik Sameena ^{[1
]}

Kumar, Ethamakula Guravaiah Tiruvenkata ^{[1
]}

Swapna, Sirasanagandla ^{[1
]}

Ramesh, Bellamkonda ^{[1
]}

Rao, Chippada Appa ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Biochem, Tirupati 517502, Andhra Pradesh, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 04期

关键词：

Amberlite-XAD-16; Antihyperglycemic; Antihyperlipidemic; Bioassay guided-fractionation; HbA(1C); Sephadex-LH-20; ETHANOLIC EXTRACT; SERUM; PLASMA; GLYCOGEN; FRUIT; LIPOPROTEINS; METABOLISM; ENZYMES; CUMINI; LEAVES;

D O I：

10.1016/j.fct.2010.01.029

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present study was taken up to identify potent antihyperglycemic fraction from the aqueous extract of Syzygium alternifolium (SA) seeds, using bioassay guided fractionation. The isolated fraction C at a dose of 50 mg/kg.b.w produced the maximum fall of 83% in the blood glucose level in the diabetic rats after 6 h of the treatment. The administration of fraction C (50 mg/kg.b.w) once daily for 30 days in STZ diabetic rats resulted in a significant decrease in blood glucose, glycosylated haemoglobin with a significant rise in plasma insulin level. Further fraction C showed antihyperlipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C, VLDL-C levels coupled together with elevation of HDL-C level in diabetic rats. A significant decrease in the activities of SCOT, SGPT, ALP and decreased levels of serum urea and creatinine in diabetic treated rats when compared to diabetic untreated rats, indicate the protective role against liver and kidney damage and non-toxic property of the fraction C. A comparison was made between the action of fraction C and antidiabetic drug glibenclamide (20 mg/kg.b.w). The effect of fraction C was more prominent when compared to that of glibenclamide. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1078 / 1084

页数：7

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