Oxidation of nuclear thioredoxin during oxidative stress

被引：87
|
作者：
Watson, WH [1 ]
Jones, DP [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
来源：
FEBS LETTERS | 2003年 / 543卷 / 1-3期
关键词：
thioredoxin; redox; oxidative stress; nucleus; protein oxidation; glutathione;
D O I：
10.1016/S0014-5793(03)00430-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thioredoxin 1 (Trx1) is a key redox control system within the nucleus, yet little is known about the sensitivity of nuclear Trx1 to oxidative stress. The present study compared oxidant-induced changes in the redox states of nuclear Trx1, cytoplasmic Trx1, and cellular glutathione (GSH). Nuclear Trx1 was more reducing than cytoplasmic Trx1 and cellular GSH in proliferating cells. tert-Butylhydroperoxide caused an increase in the total amount of nuclear Trx1, but this was accompanied by a 60 mV oxidation. Thus, the increase in nuclear Trx1 levels did not correspond to an increase in the overall reducing capacity of Trx1 in the nucleus. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：144 / 147
页数：4
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