Investigation of the nephroprotective effect of dexmedetomidine on colistin-induced nephrotoxicity in rats

被引:3
作者
Canakci, Ebru [1 ]
Karatas, Ahmet [1 ,2 ]
Coskun, Ilker [1 ]
Benli, Erdal [1 ,3 ]
Altinbas, Ali [1 ]
Akcay Celik, Muruvvet [1 ,4 ]
Bayrak, Tulin [1 ,5 ]
Bayrak, Ahmet [1 ,5 ]
机构
[1] Ordu Univ, Fac Med, Dept Anesthesiol & Reanimat, Nefs I Bucak St, Ordu, Turkey
[2] Ondokuz Mayis Univ, Dept Nephrol, Fac Med, Samsun, Turkey
[3] Ordu Univ, Fac Med, Dept Urol Surg, Ordu, Turkey
[4] Ordu Univ, Fac Med, Dept Med Pathol, Ordu, Turkey
[5] Ordu Univ, Dept Med Biochem, Fac Med, Ordu, Turkey
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2022年 / 123卷 / 08期
关键词
rat; colistin; nephrotoxicity; dexmedetomidine; ISCHEMIA-REPERFUSION INJURY; ACUTE KIDNEY INJURY; RENAL-FUNCTION; INFUSION;
D O I
10.4149/BLL_2022_094
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exerts a protective effect on colistin nephrotoxicity. Our study aims to investigate the nephroprotective effect of dexmedetomidine in an experimental model of nephrotoxicity in rats. METHODS: The control group was administered saline (SF) intraperitoneally twice a day. The colistin group received an intraperitoneal (ip) injection of 10 mg/kg of colistin twice a day. The DX10 group received 10 mg/ kg of colistin 20 minutes after the intraperitoneal injection of 10 mcg/kg of dexmedetomidine. The DX20 group received 10 mg/kg of colistin 20 minutes after the intraperitoneal injection of 20 mcg/kg of dexmedetomidine. Applications were continued for 7 days, twice a day. All rats were sacrificed on the 8th day after blood and kidney tissue samples were taken. BUN, Creatine, KIM-1 and Endothelin-1 were studied in blood samples. RESULTS: There was a significant difference in the median values of Urea, BUN and Creatine between the groups (p<0.001, p<0.001, p<0.001, respectively). There was a significant difference in the median values of KIM-1 and Endothelin-1 between the groups (p=0.009, p=0.001, respectively). A significant difference was observed between the histopathological scores of the groups (p<0.001). CONCLUSION: Dexmedetomidine significantly decreased the elevated levels of BUN, Creatinine, KIM-1, and Endothelin-1 induced by colistin. Dexmedetomidine, at both doses, histopathologically prevented apoptosis and reduced the number of necrotic cells in the kidneys. Dexmedetomidine provides renoprotective effects, therefore it is a valuable sedation agent for clinicians working in intensive care units (Tab. 2, Fig. 4, Ref. 19). Text in PDF www.elis.sk
引用
收藏
页码:579 / 584
页数:6
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