Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

被引：38

作者：

Tarannum, Mubin ^{[1
]}

Romee, Rizwan ^{[1
]}

Shapiro, Roman M. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Harvard Med Sch, Div Stem Cell Transplant & Cellular Therapy, Boston, MA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

natural Killer (NK) cell; immunotherapy; in vitro expansion; tumor infiltrating cell; NK cell exhaustion; NATURAL-KILLER-CELLS; EX-VIVO EXPANSION; TUMOR MICROENVIRONMENT; ADOPTIVE TRANSFER; SOLID TUMORS; ANTITUMOR-ACTIVITY; T-CELLS; RECEPTOR; LEUKEMIA; ANTIBODY;

D O I：

10.3389/fimmu.2022.859177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer cells constitute a part of the innate immune system that mediates an effective immune response towards virus-infected and malignant cells. In recent years, research has focused on exploring and advancing NK cells as an active immunotherapy platform. Despite major advances, there are several key challenges that need to be addressed for the effective translation of NK cell research to clinical applications. This review highlights some of these challenges and the innovative strategies being developed to overcome them, including in vitro expansion, in vivo persistence, infiltration to the tumor site, and prevention of exhaustion.

引用

页数：12

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