The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss

被引：6

作者：

Lalonde, Chloe S. ^{[1
]}

Teng, Yong ^{[2
]}

Burtness, Barbara A. ^{[3
]}

Ferris, Robert L. ^{[4
]}

Ahmed, Rafi ^{[5
]}

Saba, Nabil F. ^{[2
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[2] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA

[3] Yale Sch Med, Dept Med Oncol, New Haven, CT USA

[4] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA

[5] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2022年 / 114卷 / 10期

关键词：

HUMAN-PAPILLOMAVIRUS VACCINATION; CANCER INCIDENCE; NATURAL-HISTORY; CERVICAL-CANCER; IMMUNOGENICITY; ADOLESCENTS; INFECTIONS; PREVALENCE; EFFICACY; WOMEN;

D O I：

10.1093/jnci/djac098

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oropharyngeal squamous cell carcinoma (OPSCC) accounts for more than half of all head and neck cancers. Since the 1970s, OPSCC has shifted from an environmentally triggered to virally mediated disease due to a sharp rise in human papillomavirus (HPV)-related squamous cell carcinoma. Although a highly effective prophylactic vaccine is available, its current implementation is far below national targets, and OPSCC incidence is predicted to further increase by 2045. However, we believe that with prompt action now, we can not only defy these predictions but also effectively eradicate HPV-related OPSCC in these next 20 years. We herein provide an overview of the necessary elements to eliminate this disease: improved primary vaccine uptake, a 1-time universal vaccination effort, and implementation of novel therapeutics that have potential to cure existing disease.

引用

页码：1333 / 1337

页数：5

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