Absence of TetB identifies minocycline-susceptible isolates of Acinetobacter baumannii
被引:15
作者:
Lomovskaya, Olga
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The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
The Med Co, Infect Dis, Biol, 3013 Sci Pk Rd,1st Floor, San Diego, CA 92121 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Lomovskaya, Olga
[1
,4
]
Sun, Dongxu
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The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Sun, Dongxu
[1
]
Rubio-Aparicio, Debora
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The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Rubio-Aparicio, Debora
[1
]
Nelson, Kirk J.
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The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Nelson, Kirk J.
[1
]
Thamlikitkul, Visanu
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Mahidol Univ, Siriraj Hosp, Dept Med, Div Infect Dis & Trop Med,Fac Med, Bangkok 10700, ThailandThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Thamlikitkul, Visanu
[2
]
Dudley, Michael N.
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The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Dudley, Michael N.
[1
]
Redell, Mark A.
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Melinta Therapeut, 300 George St, New Haven, CT 06511 USAThe Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Redell, Mark A.
[3
]
机构:
[1] The Med Co, 3013 Sci Pk Rd, San Diego, CA 92121 USA
Minocycline is one of the few options available to treat infections caused by Acinetobacter baumannii. Acquired resistance to minocycline in A. baumannii is associated with presence of the TetB efflux pump. Previous studies suggested that the absence of tetB may predict minocycline minimum inhibitory concentrations (MICs) of <= 4 mu g/mL. In this study, a collection of 258 A. baumannii isolates was used to generate MIC frequency distributions for the tetB-positive and -negative sets of isolates. Of the 93 tetB -negative strains, all had minocycline MICs <= 4 mu g/mL, resulting in a negative predictive value of 100%. Of the 165 tetB-positive strains, 154 had minocycline MICs > 4 mu g/mL, resulting in a positive predictive value of 93.3%. In conclusion, this study shows that tetB is highly associated with MICs above the current US Food and Drug Administration (FDA) and Clinical and Laboratory Standards Institute (CLSI) susceptible breakpoint of 4 mu g/mL. (c) 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Akers, Kevin S.
Mende, Katrin
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Infect Dis Clin Res Program, San Antonio, TX USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Mende, Katrin
Yun, Heather C.
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h-index: 0
机构:
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Yun, Heather C.
Hospenthal, Duane R.
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h-index: 0
机构:
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Hospenthal, Duane R.
Beckius, Miriam L.
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h-index: 0
机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Beckius, Miriam L.
Yu, Xin
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机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Yu, Xin
Murray, Clinton K.
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h-index: 0
机构:
Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
机构:
Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Tufts Univ, Div Geog Med & Infect Dis, Boston, MA 02111 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Boucher, Helen W.
Talbot, George H.
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h-index: 0
机构:
Talbot Advisors, Wayne, PA USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Talbot, George H.
Bradley, John S.
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h-index: 0
机构:
Rady Childrens Hosp San Diego, Div Infect Dis, San Diego, CA USA
Univ Calif San Diego, San Diego, CA 92103 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Bradley, John S.
Edwards, John E., Jr.
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h-index: 0
机构:
Harbor Univ Calif Los Angeles, Med Ctr, Div Infect Dis, Los Angeles, CA USA
Los Angeles Biomed Res Inst, Torrance, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Edwards, John E., Jr.
Gilbert, David
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h-index: 0
机构:
Providence Portland Med Ctr, Div Infect Dis, Portland, OR USA
Oregon Hlth & Sci Univ, Portland, OR 97201 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Gilbert, David
Rice, Louis B.
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h-index: 0
机构:
Louis Stokes Cleveland Vet Adm Med Ctr, Med Serv, Cleveland, OH USA
Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Rice, Louis B.
Scheld, Michael
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h-index: 0
机构:
Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Scheld, Michael
Spellberg, Brad
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h-index: 0
机构:
Harbor Univ Calif Los Angeles, Med Ctr, Div Infect Dis, Los Angeles, CA USA
Los Angeles Biomed Res Inst, Torrance, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Spellberg, Brad
Bartlett, John
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h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Hornsey, Michael
Ellington, Matthew J.
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机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Ellington, Matthew J.
Doumith, Michel
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机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Doumith, Michel
Thomas, Claire P.
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机构:
Hammersmith Hosp, Imperial Coll Healthcare NHS Trust, London W12 0HS, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Thomas, Claire P.
Gordon, Nicola C.
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机构:
Barts & London NHS Trust, Div Infect, London E1 2ES, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Gordon, Nicola C.
Wareham, David W.
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Barts & London NHS Trust, Div Infect, London E1 2ES, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Wareham, David W.
Quinn, John
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h-index: 0
机构:
Chicago Infect Dis Res Inst, Chicago, IL 60614 USAHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Quinn, John
Lolans, Karen
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机构:
Chicago Infect Dis Res Inst, Chicago, IL 60614 USAHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Lolans, Karen
Livermore, David M.
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机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Livermore, David M.
Woodford, Neil
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机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Akers, Kevin S.
Mende, Katrin
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h-index: 0
机构:
Infect Dis Clin Res Program, San Antonio, TX USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Mende, Katrin
Yun, Heather C.
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h-index: 0
机构:
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Yun, Heather C.
Hospenthal, Duane R.
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h-index: 0
机构:
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Hospenthal, Duane R.
Beckius, Miriam L.
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h-index: 0
机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Beckius, Miriam L.
Yu, Xin
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h-index: 0
机构:Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Yu, Xin
Murray, Clinton K.
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h-index: 0
机构:
Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USABrooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA
机构:
Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Tufts Univ, Div Geog Med & Infect Dis, Boston, MA 02111 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Boucher, Helen W.
Talbot, George H.
论文数: 0引用数: 0
h-index: 0
机构:
Talbot Advisors, Wayne, PA USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Talbot, George H.
Bradley, John S.
论文数: 0引用数: 0
h-index: 0
机构:
Rady Childrens Hosp San Diego, Div Infect Dis, San Diego, CA USA
Univ Calif San Diego, San Diego, CA 92103 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Bradley, John S.
Edwards, John E., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Harbor Univ Calif Los Angeles, Med Ctr, Div Infect Dis, Los Angeles, CA USA
Los Angeles Biomed Res Inst, Torrance, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Edwards, John E., Jr.
Gilbert, David
论文数: 0引用数: 0
h-index: 0
机构:
Providence Portland Med Ctr, Div Infect Dis, Portland, OR USA
Oregon Hlth & Sci Univ, Portland, OR 97201 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Gilbert, David
Rice, Louis B.
论文数: 0引用数: 0
h-index: 0
机构:
Louis Stokes Cleveland Vet Adm Med Ctr, Med Serv, Cleveland, OH USA
Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Rice, Louis B.
Scheld, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Scheld, Michael
Spellberg, Brad
论文数: 0引用数: 0
h-index: 0
机构:
Harbor Univ Calif Los Angeles, Med Ctr, Div Infect Dis, Los Angeles, CA USA
Los Angeles Biomed Res Inst, Torrance, CA USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
Spellberg, Brad
Bartlett, John
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USATufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Hornsey, Michael
Ellington, Matthew J.
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Ellington, Matthew J.
Doumith, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Doumith, Michel
Thomas, Claire P.
论文数: 0引用数: 0
h-index: 0
机构:
Hammersmith Hosp, Imperial Coll Healthcare NHS Trust, London W12 0HS, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Thomas, Claire P.
Gordon, Nicola C.
论文数: 0引用数: 0
h-index: 0
机构:
Barts & London NHS Trust, Div Infect, London E1 2ES, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Gordon, Nicola C.
Wareham, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Barts & London NHS Trust, Div Infect, London E1 2ES, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Wareham, David W.
Quinn, John
论文数: 0引用数: 0
h-index: 0
机构:
Chicago Infect Dis Res Inst, Chicago, IL 60614 USAHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Quinn, John
Lolans, Karen
论文数: 0引用数: 0
h-index: 0
机构:
Chicago Infect Dis Res Inst, Chicago, IL 60614 USAHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Lolans, Karen
Livermore, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England
Livermore, David M.
Woodford, Neil
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, EnglandHlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England