A New Microporous Ca(II) Metal-Organic Framework for 5-Fluorouracil Loading and Inhibition of Human Osteogenic Sarcoma Cells

被引：0
|
作者：
Zhang, Li-Yuan [1 ]
Zhang, Fan [1 ]
Chen, Xiang-Yi [2 ]
Wu, Hui-Ming [1 ]
机构：
[1] Wenzhou Hosp Tradit Chinese Med, Dept Osteol, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Hosp Tradit Chinese Med, Dept Gynecol, Wenzhou, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 06期
关键词：
encapsulation; osteogenic sarcoma; three-dimensional; X-ray;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new three-dimensional porous coordination polymer with the formula of [Ca-3(BTATB)(2) (H2O)(2)](DMF)(3) (1) has been solvothermally synthesized from 4,4', 4''-(benzene-1,3,5-triyltris(azanediyl)) tribenzoate (H3BTATB) and Ca(NO3) 2.4H(2)O under DMF media and characterized by single crystal X-ray diffraction and elemental analysis. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-Fu) on the desolvated 1 (1a) has been studied by grand canonical Monte Carlo (GCMC) simulation. In addition, in vitro anticancer activity of compounds 1 and 5-Fu loaded 1a on four human osteogenic sarcoma cell lines (MG63, HOS, U2OS and 143B) have also been evaluated using MTT assay.
引用
收藏
页码：1125 / 1129
页数：5
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