Nitric oxide affects LTP in area CA1 and CA3 of hippocampus in low-level lead-exposed rat

被引：29

作者：

Xu, YZ ^{[1
]}

Ruan, DY ^{[1
]}

Wu, Y ^{[1
]}

Jiang, YB ^{[1
]}

Chen, SY ^{[1
]}

Chen, JT ^{[1
]}

Shi, P ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Biol, Hefei 230027, Anhui, Peoples R China

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1998年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

lead; nitric oxide; LTP; hippocampal slice;

D O I：

10.1016/S0892-0362(97)00072-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neonatal Wistar rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations in EPSPs in areas CA1 and CA3 of hippocampal slices of 60-day-old adult rats following developmental lead exposure were studied. The results demonstrate that lead exposure in neonatal rats causes a decrease in LTP in area CA1 and an increase in LTP in area CA3. The effects of exposure to NO-generating compound sodium nitroprusside (SNP) on LTP in areas CA1 and CA3 of control and lead-exposed rats were also tested. The data demonstrate that NO causes an increase in LTP in area CA1 and no different alterations in area CA3 of lead-exposed rats. The results also demonstrate that NO may be a messenger molecule in areas CA1 and CA3. It suggests that lead might selectively interfere with specific neurochemical pathways in the hippocampus. (C) 1998 Elsevier Science Inc.

引用

页码：69 / 73

页数：5