Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones

被引：18

作者：

Chen, En ^{[1
]}

Shao, Jiaan ^{[2
]}

Tang, Pai ^{[1
]}

Shu, Ke ^{[1
]}

Chen, Wenteng ^{[1
]}

Yu, Yongping ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

来源：

GREEN CHEMISTRY | 2018年 / 20卷 / 16期

基金：

中国国家自然科学基金;

关键词：

MULTICOMPONENT REACTIONS; DOMINO APPROACH; FUNCTIONALIZATION; CYCLIZATION; 1,3-OXAZINES; HETEROCYCLES; DIVERSITY; METAL; TOOL;

D O I：

10.1039/c8gc01766b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot, catalyst-free, three-component sequential double-annulation from amine alcohols, glyoxal monohydrates and KSCN underwent imine formation/intramolecular cyclization/[3 + 2] cycloaddition. This tandem and green reaction offered [1,3] oxazine N-fused imidazole-2-thiones in a mild condition, with a very short reaction time, wide variation in functional groups, high efficacy on the gram-large scale and followed group-assisted purification chemistry work-up.

引用

页码：3696 / 3699

页数：4

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