Modes of MAPK substrate recognition and control

被引:97
作者
Pitzschke, Andrea [1 ]
机构
[1] Univ Nat Resources & Appl Life Sci BOKU, Dept Appl Genet & Cell Biol DAGZ, A-1190 Vienna, Austria
基金
奥地利科学基金会;
关键词
MAPK; phosphorylation; stress signalling; peptide motifs; ACTIVATED PROTEIN-KINASE; TARGETED TRANSGENE INTEGRATION; TRANSCRIPTION FACTOR; ARABIDOPSIS-THALIANA; GENE FAMILY; PLANT MAPK; PHYTOALEXIN BIOSYNTHESIS; ETHYLENE BIOSYNTHESIS; RNA INTERFERENCE; STRESS TOLERANCE;
D O I
10.1016/j.tplants.2014.09.006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Mitogen-activated protein kinase (MARK) cascades are universal, evolutionary conserved signalling modules, which translate environmental information into appropriate responses via phosphorylation of their substrate proteins. In Arabidopsis, the MARK MPK3 regulates numerous cellular processes, including the adaptation to abiotic and biotic stresses. The molecular steps immediately downstream of MPK3 induction have, therefore, received abundant attention, and a respectable number of MPK3 targets are known by now. These proteins illustrate the substrate promiscuity of MPK3. They also are evidence for how manifold phosphorylation-regulated functions can be. This review presents the current knowledge about the function and regulation of MPK3-targeted proteins, takes a close look at their primary protein sequences, and proposes a model of how MPK3 recognises, binds, and phosphorylates its targets.
引用
收藏
页码:49 / 55
页数:7
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