Toward benign syntheses of pyridines involving sequential solvent free aldol and Michael addition reactions

被引：153
作者：
Cave, GWV [1 ]
Raston, CL [1 ]
机构：
[1] Monash Univ, Sch Chem, Ctr Green Chem, Melbourne, Vic 3800, Australia
来源：
CHEMICAL COMMUNICATIONS | 2000年 / 22期
关键词：
D O I：
10.1039/b007431o
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Krohnke type pyridines are readily accessible via a sequential solventless aldol condensation and Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a one pot reaction, which enables both symmetrical and unsymmetrical 2,6-bisaryl substituted pyridines to be isolated in high yield, typically > 75%.
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收藏
页码：2199 / 2200
页数：2
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