Toward benign syntheses of pyridines involving sequential solvent free aldol and Michael addition reactions

被引：153

作者：

Cave, GWV ^{[1
]}

Raston, CL ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Ctr Green Chem, Melbourne, Vic 3800, Australia

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 22期

关键词：

D O I：

10.1039/b007431o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Krohnke type pyridines are readily accessible via a sequential solventless aldol condensation and Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a one pot reaction, which enables both symmetrical and unsymmetrical 2,6-bisaryl substituted pyridines to be isolated in high yield, typically > 75%.

引用

页码：2199 / 2200

页数：2

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