Interferon therapy-responsive brain metabolic abnormalities in a case of adult-onset subacute sclerosing panencephalitis evaluated by 1H MRS analysis

被引:7
作者
Takashima, H
Eriguchi, M
Nakamura, T
Satoh, J
Kuroda, Y
Udono, H
Uchino, A
机构
[1] Saga Med Sch, Dept Internal Med, Div Neurol, Saga 8498501, Japan
[2] Saga Med Sch, Dept Neurosurg, Saga 8498501, Japan
[3] Saga Med Sch, Dept Radiol, Saga 8498501, Japan
关键词
subacute sclerosing panencephalitis; adult-onset; magnetic resonance spectroscopy; interferon-beta;
D O I
10.1016/S0022-510X(02)00360-X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We describe a 22-year-old woman with an adult-onset, slowly progressive form of subacute sclerosing panencephalitis (SSPE), who was repeatedly evaluated by brain magnetic resonance spectroscopy (MRS). The brain lesion spectrum showed a decrease in N-acetylaspartate (NAA) resonance, an increase in inositol (Ins) resonance, and an unaltered choline signal. These findings suggest neuronal loss and reactive gliosis without inflammation, consistent with brain biopsy findings showing astrocytic proliferation unaccompanied by lymphocytic infiltrates. The unusually protracted clinical course might be attributable to an absence of inflammatory infiltrates in the brain. Intraventricular interferon injection plus oral inosine pranobex treatment produced a substantial improvement in the MRS findings, suggesting the validity of monitoring MRS in SSPE. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:59 / 63
页数:5
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